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dc.contributor.authorKucukaydin, Zehra
dc.contributor.authorDuran, Cevdet
dc.contributor.authorBasaran, Mustafa
dc.contributor.authorCamlica, Fatos
dc.contributor.authorErdem, Sami Said
dc.contributor.authorBasaran, Ahmet
dc.contributor.authorGonen, Mustafa Sait
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T15:56:58Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T15:56:58Z
dc.date.issued2016
dc.identifier.issn1720-8386
dc.identifier.urihttps://dx.doi.org/10.1007/s40618-016-0498-5
dc.identifier.urihttp://hdl.handle.net/11446/2423
dc.descriptionWOS: 000383571900007en_US
dc.descriptionPubMed ID: 27300033en_US
dc.description.abstractPurpose Insulin resistance (IR) and increased oxidative stress (OS) are the characteristics of polycystic ovary syndrome (PCOS). In this study, we aimed to evaluate the effects of oral glucose tolerance (OGTT) and mixed meal tests (MMT) on plasma total oxidant (TOS) and total antioxidant status (TAS) in patients with PCOS and the relationship between these parameters and IR, calculated via homeostasis of model assessment-IR (HOMA-IR) and Matsuda's insulin sensitivity index (ISI) derived from OGTT and MMT. Methods Twenty-two patients with PCOS, and age- and body mass index (BMI)-matched 20 women as controls were enrolled into the study. Five-hour OGTT and MMT were performed on different days, and before and after these tests, plasma TOS and TAS levels were investigated. IR was calculated with HOMA-IR and Matsuda's ISI. Results HOMA-IR levels were higher in patients with PCOS, compared to controls, while Matsuda's ISI derived from OGTT and MMT was higher in controls. Plasma TOS levels before OGTT and MMT were higher in patients with PCOS than controls, while TAS levels were similar. After OGTT, plasma TOS levels became decreased at 5th hour, when compared to baseline values in PCOS group. Likewise, the same decrement was found in controls, but the decrement was not significant. After OGTT and MMT at 5th hour, no changes were observed in TAS levels, compared to baseline. Conclusion Matsuda's ISIs derived from OGTT and MMT can be used instead of each other, and interestingly, we found a decrease in TOS levels after OGTT in patients with PCOS.en_US
dc.description.sponsorshipKonya Training and Research Hospital's Research Funden_US
dc.description.sponsorshipThis study was supported by Konya Training and Research Hospital's Research Fund.en_US
dc.language.isoengen_US
dc.publisherSPRINGERen_US
dc.identifier.doi10.1007/s40618-016-0498-5en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectInsulin resistanceen_US
dc.subjectOral glucose tolerance testen_US
dc.subjectMixed meal testen_US
dc.subjectTotal oxidant statusen_US
dc.subjectTotal antioxidant statusen_US
dc.titlePlasma total oxidant and antioxidant status after oral glucose tolerance and mixed meal tests in patients with polycystic ovary syndromeen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF ENDOCRINOLOGICAL INVESTIGATIONen_US
dc.departmentDBÜen_US
dc.identifier.issue10en_US
dc.identifier.volume39en_US
dc.identifier.startpage1139en_US
dc.identifier.endpage1148en_US
dc.contributor.authorID0000-0002-1089-623Xen_US
dc.contributor.authorID0000-0001-5908-2408en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Kucukaydin, Zehra -- Basaran, Mustafa -- Basaran, Ahmet] Konya Training & Res Hosp, Div Obstet & Gynecol, Konya, Turkey -- [Duran, Cevdet] Konya Training & Res Hosp, Div Endocrinol & Internal Med, Div Endocrinol & Metab, TR-42100 Meram, Konya, Turkey -- [Camlica, Fatos] Ermenek State Hosp, Ermenek, Karaman, Turkey -- [Erdem, Sami Said] Konya Training & Res Hosp, Div Biochem, Konya, Turkey -- [Kutlu, Orkide] Okmeydani Training & Res Hosp, Div Internal Med, Istanbul, Turkey -- [Burnik, Ferda Sevimli] Konya Training & Res Hosp, Div Endocrinol & Internal Med, Konya, Turkey -- [Elmas, Halis] Konya Training & Res Hosp, Div Internal Med, Konya, Turkey -- [Gonen, Mustafa Sait] Istanbul Bilim Univ, Fac Med, Div Endocrinol & Internal Med, Istanbul, Turkeyen_US


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