dc.contributor.author | Kucukaydin, Zehra | |
dc.contributor.author | Duran, Cevdet | |
dc.contributor.author | Basaran, Mustafa | |
dc.contributor.author | Camlica, Fatos | |
dc.contributor.author | Erdem, Sami Said | |
dc.contributor.author | Basaran, Ahmet | |
dc.contributor.author | Gonen, Mustafa Sait | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:56:58Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:56:58Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1720-8386 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s40618-016-0498-5 | |
dc.identifier.uri | http://hdl.handle.net/11446/2423 | |
dc.description | WOS: 000383571900007 | en_US |
dc.description | PubMed ID: 27300033 | en_US |
dc.description.abstract | Purpose Insulin resistance (IR) and increased oxidative stress (OS) are the characteristics of polycystic ovary syndrome (PCOS). In this study, we aimed to evaluate the effects of oral glucose tolerance (OGTT) and mixed meal tests (MMT) on plasma total oxidant (TOS) and total antioxidant status (TAS) in patients with PCOS and the relationship between these parameters and IR, calculated via homeostasis of model assessment-IR (HOMA-IR) and Matsuda's insulin sensitivity index (ISI) derived from OGTT and MMT. Methods Twenty-two patients with PCOS, and age- and body mass index (BMI)-matched 20 women as controls were enrolled into the study. Five-hour OGTT and MMT were performed on different days, and before and after these tests, plasma TOS and TAS levels were investigated. IR was calculated with HOMA-IR and Matsuda's ISI. Results HOMA-IR levels were higher in patients with PCOS, compared to controls, while Matsuda's ISI derived from OGTT and MMT was higher in controls. Plasma TOS levels before OGTT and MMT were higher in patients with PCOS than controls, while TAS levels were similar. After OGTT, plasma TOS levels became decreased at 5th hour, when compared to baseline values in PCOS group. Likewise, the same decrement was found in controls, but the decrement was not significant. After OGTT and MMT at 5th hour, no changes were observed in TAS levels, compared to baseline. Conclusion Matsuda's ISIs derived from OGTT and MMT can be used instead of each other, and interestingly, we found a decrease in TOS levels after OGTT in patients with PCOS. | en_US |
dc.description.sponsorship | Konya Training and Research Hospital's Research Fund | en_US |
dc.description.sponsorship | This study was supported by Konya Training and Research Hospital's Research Fund. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER | en_US |
dc.identifier.doi | 10.1007/s40618-016-0498-5 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Polycystic ovary syndrome | en_US |
dc.subject | Insulin resistance | en_US |
dc.subject | Oral glucose tolerance test | en_US |
dc.subject | Mixed meal test | en_US |
dc.subject | Total oxidant status | en_US |
dc.subject | Total antioxidant status | en_US |
dc.title | Plasma total oxidant and antioxidant status after oral glucose tolerance and mixed meal tests in patients with polycystic ovary syndrome | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.volume | 39 | en_US |
dc.identifier.startpage | 1139 | en_US |
dc.identifier.endpage | 1148 | en_US |
dc.contributor.authorID | 0000-0002-1089-623X | en_US |
dc.contributor.authorID | 0000-0001-5908-2408 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Kucukaydin, Zehra -- Basaran, Mustafa -- Basaran, Ahmet] Konya Training & Res Hosp, Div Obstet & Gynecol, Konya, Turkey -- [Duran, Cevdet] Konya Training & Res Hosp, Div Endocrinol & Internal Med, Div Endocrinol & Metab, TR-42100 Meram, Konya, Turkey -- [Camlica, Fatos] Ermenek State Hosp, Ermenek, Karaman, Turkey -- [Erdem, Sami Said] Konya Training & Res Hosp, Div Biochem, Konya, Turkey -- [Kutlu, Orkide] Okmeydani Training & Res Hosp, Div Internal Med, Istanbul, Turkey -- [Burnik, Ferda Sevimli] Konya Training & Res Hosp, Div Endocrinol & Internal Med, Konya, Turkey -- [Elmas, Halis] Konya Training & Res Hosp, Div Internal Med, Konya, Turkey -- [Gonen, Mustafa Sait] Istanbul Bilim Univ, Fac Med, Div Endocrinol & Internal Med, Istanbul, Turkey | en_US |