Yazar "Akman, Özlem" için İstanbul Bilim Üniversitesi Makale Koleksiyonu listeleme
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Comparative proteomic approach in rat model of absence epilepsy.
Gürol, Gönül; Demiralp, Duygu Özel; Yılmaz, Ayça Kasapoğlu; Akman, Özlem; Ateş, Nurbay; Karson, Ayşe (Humana Press, 2015)The aim of this study was to investigate cellular proteins in the pathogenesis of the genetic rat model of absence epilepsy. Protein spots were identified with peptide mass fingerprinting analysis using matrix-assisted ... -
Early life status epilepticus and stress have distinct and sex-specific effects on learning, subsequent seizure outcomes, including anticonvulsant response to phenobarbital.
Akman, Özlem; Moshé, Solomon L.; Galanopoulou, Aristea S. (Wiley Pub., 2015)Aims: Neonatal status epilepticus (SE) is often associated with adverse cognitive and epilepsy outcomes. We investigate the effects of three episodes of kainic acid-induced SE (3KA-SE) and maternal separation in immature ... -
The effect of memantine in harmaline-induced tremor and neurodegeneration
İşeri, Pervin K.; Karson, Ayşe; Güllü, Kemal M.; Akman, Özlem; Köktürk, Sibel; Yardımoğlu, Melda; Ateş, Nurbay (Elsevier Inc, 2011)Essential tremor (ET) is one of the most common and most disabling movement disorders among adults. The drug treatment of ET remains unsatisfactory. Additional therapies are required for patients with inadequate response ... -
Electroencephalographic differences between WAG/Rij and GAERS rat models of absence epilepsy
Akman, Özlem; Demiralp, Tamer; Ates, Nurbay; Onat, Filiz Yilmaz (Elsevier Inc, 2010)The inbred Wistar Albino Glaxo Rats from Rijswijk (WAG/Rij) and the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are well-validated genetic models of absence epilepsy. Although they share similar characteristics ... -
The gamma-butyrolactone model of absence epilepsy: acute and chronic effects in wistar rats
Karamahmutoğlu, Tuğba Eryiğit; Çarçak, Nihan; Şahiner, Melike; Akman, Özlem; Snead, O. Carter; Eşkazan, Esat; Onat, Filiz (Türk Epilepsi ile Savaş Derneği, 2013)Objective: We studied the electroencephalographic (EEG) and behavioral changes of the chemical model of generalized absence epilepsy induced by acute and chronic administration of gamma-butrolactone (GBL), a prodrug of ... -
The gamma-butyrolactone model of absence epilepsy: Acute and chronic effects in wistar rats
Karamahmutoğlu, Tuğba Eryiğit; Çarçak, Nihan; Şahiner, Melike; Akman, Özlem; Snead, O. Carter; Eşkazan, Esat; Onat, Filiz (Türk Epilepsi İle Savaş Derneği, 2013)Introduction A pharmacological modeling approach to absence epilepsy requires a reproducible and predictable method that has the EEG and behavioral characteristics of generalized typical absence seizures in humans. The ... -
Perirhinal cortical kindling in rats with genetic absence epilepsy
Akman, Özlem; Karson, Ayşe; Aker, Rezzan Gülhan; Ateş, Nurbay; Onat, Filiz Yılmaz (Elsevier Inc, 2010)Two genetic models of absence epilepsy, GAERS and WAG/Rij rat strains, are resistant to progression of partial seizures induced by amygdaloid or hippocampal kindling. Perirhinal cortex is one of the crucial areas for the ... -
Sex-specific consequences of early life seizures
Akman, Özlem; Moshé, Solomon L.; Galanopoulou, Aristea S. (Elsevier Inc, 2014)Seizures are very common in the early periods of life and are often associated with poor neurologic outcome in humans. Animal studies have provided evidence that early life seizures may disrupt neuronal differentiation and ...