• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   DSpace Home
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
  • WoS İndeksli Yayınlar Koleksiyonu
  • View Item
  •   DSpace Home
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
  • WoS İndeksli Yayınlar Koleksiyonu
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Exogenously administered adenosine attenuates renal damage in streptozotocin-induced diabetic rats

Date

2016

Author

Taskiran, Emin
Erbas, Oytun
Yigitturk, Gurkan
Meral, Ayfer
Akar, Harun
Taskiran, Dilek

Metadata

Show full item record

Abstract

Background: Diabetic nephropathy (DNP) is one of the most serious complications of diabetes mellitus (DM). In the present study, we investigated the potential of adenosine as a therapeutic candidate for preventing DNP.Methods: Twenty-one adult male rats were included in the study. Fourteen rats were administered a single dose of 60mg/kg streptozotocin (STZ) to induce diabetes. Seven rats served as normal control group. Diabetic rats were randomly divided into two groups: one group was treated with 1mL/kg saline/day (DM+saline) and the other group was treated with 5mg/kg/day adenosine (DM+adenosine) for 6weeks. After 6weeks, biochemical parameters including urea, creatinine, blood urea nitrogen (BUN), kidney injury molecule-1 (KIM-1) and tumor necrosis factor- (TNF-) were measured in plasma samples. Also, kidneys were removed for histopathological assessment.Results: Both of plasma KIM-1 and TNF- levels were significantly higher in DM+saline group compared to controls. However, treatment of diabetic rats with adenosine significantly decreased the plasma KIM-1 and TNF- levels compared to DM+saline group. Significant histopathological changes were observed in diabetic rats whereas adenosine treatment effectively prevented these changes.Conclusions: The findings of the present study suggest that adenosine may be a useful therapeutic agent for preventing DNP.

Source

RENAL FAILURE

Volume

38

Issue

8

URI

https://dx.doi.org/10.1080/0886022X.2016.1207054
http://hdl.handle.net/11446/2446

Collections

  • PubMed İndeksli Yayınlar Koleksiyonu [1178]
  • WoS İndeksli Yayınlar Koleksiyonu [1717]



DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 




| Instruction | Guide | Contact |

DSpace@DBU

by OpenAIRE
Advanced Search

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeLanguageDepartmentCategoryPublisherAccess TypeInstitution AuthorThis CollectionBy Issue DateAuthorsTitlesSubjectsTypeLanguageDepartmentCategoryPublisherAccess TypeInstitution Author

My Account

LoginRegister

Statistics

View Google Analytics Statistics

DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 


|| Instruction || Guide || Library || Demiroğlu Bilim University || OAI-PMH ||

Demiroğlu Bilim University Library, İstanbul, Turkey
If you find any errors in content please report us

Creative Commons License
Demiroğlu Bilim University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace@DBU:


DSpace 6.2

tarafından İdeal DSpace hizmetleri çerçevesinde özelleştirilerek kurulmuştur.