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dc.contributor.authorTaskiran, Emin
dc.contributor.authorErbas, Oytun
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorMeral, Ayfer
dc.contributor.authorAkar, Harun
dc.contributor.authorTaskiran, Dilek
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T15:57:05Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T15:57:05Z
dc.date.issued2016
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.urihttps://dx.doi.org/10.1080/0886022X.2016.1207054
dc.identifier.urihttp://hdl.handle.net/11446/2446
dc.descriptionWOS: 000383902000018en_US
dc.descriptionPubMed ID: 27418253en_US
dc.description.abstractBackground: Diabetic nephropathy (DNP) is one of the most serious complications of diabetes mellitus (DM). In the present study, we investigated the potential of adenosine as a therapeutic candidate for preventing DNP.Methods: Twenty-one adult male rats were included in the study. Fourteen rats were administered a single dose of 60mg/kg streptozotocin (STZ) to induce diabetes. Seven rats served as normal control group. Diabetic rats were randomly divided into two groups: one group was treated with 1mL/kg saline/day (DM+saline) and the other group was treated with 5mg/kg/day adenosine (DM+adenosine) for 6weeks. After 6weeks, biochemical parameters including urea, creatinine, blood urea nitrogen (BUN), kidney injury molecule-1 (KIM-1) and tumor necrosis factor- (TNF-) were measured in plasma samples. Also, kidneys were removed for histopathological assessment.Results: Both of plasma KIM-1 and TNF- levels were significantly higher in DM+saline group compared to controls. However, treatment of diabetic rats with adenosine significantly decreased the plasma KIM-1 and TNF- levels compared to DM+saline group. Significant histopathological changes were observed in diabetic rats whereas adenosine treatment effectively prevented these changes.Conclusions: The findings of the present study suggest that adenosine may be a useful therapeutic agent for preventing DNP.en_US
dc.description.sponsorshipTurkish Kidney Disease and Hypertension Research Foundationen_US
dc.description.sponsorshipThis study was supported by Turkish Kidney Disease and Hypertension Research Foundation.en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.isversionof10.1080/0886022X.2016.1207054en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdenosineen_US
dc.subjectdiabetes mellitusen_US
dc.subjectKIM-1en_US
dc.subjectnephropathyen_US
dc.subjectTNF-alphaen_US
dc.titleExogenously administered adenosine attenuates renal damage in streptozotocin-induced diabetic ratsen_US
dc.typearticleen_US
dc.relation.journalRENAL FAILUREen_US
dc.contributor.departmentDBÜen_US
dc.identifier.issue8en_US
dc.identifier.volume38en_US
dc.identifier.startpage1276en_US
dc.identifier.endpage1282en_US
dc.contributor.authorID0000-0002-4505-0939en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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