Browsing Tıp Fakültesi Makale Koleksiyonu by Author "Diz-Küçükkaya, Reyhan"
Now showing items 1-11 of 11
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ADAMTS-13 gene expression in antiphospholipid syndrome
Hançer, Veysel Sabri; Diz-Küçükkaya, Reyhan; Topal-Sarıkaya, Ayşegül (Galenos Yayınevi, 2011)Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent thrombosis and fetal mortality. Thrombotic microangiopathy (TMA) is an important histological finding in catastrophicAPS (CAPS) and in ... -
Comparison of KRAS Mutation Tests in Colorectal Cancer Patients
Hançer, Veysel Sabri; Büyükdoğan, Murat; Türkmen, İlknur; Başsüllü, Nuray; Altuğ, Tuncay; Diz-Küçükkaya, Reyhan; Demir, Osman Gökhan (2011)The KRAS pathway and studies evaluating KRAS as a prognostic marker in colorectal cancer are discussed along with advances in KRAS gene mutation testing. Highly sensitive real-time polymerase chain reaction (PCR) methods ... -
Cytotoxic T lymphocyte antigen-4 (CTLA-4) A49G polymorphism and autoimmune blood diseases
Aktürk, Faruk; Hançer, Veysel Sabri; Diz-Küçükkaya, Reyhan (Türk Hematoloji Deerneği, 2010)Objective: The cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is expressed on T lymphocytes, and inhibits the T-cell responses. In animal models, it has been shown that complete CTLA-4 deficiency was lethal due to ... -
Diyaresi olan febril nötropenik hastalarda clostridium difficile toksin A ve B pozitifliği oranları ve epidemiyolojik özelliklerinin değerlendirilmesi
İris, Nur Efe; Demirel, Aslıhan; Koçulu, Safiye; Çevik, Esin; Ordu, Aylin; Diz-Küçükkaya, Reyhan (Türkiye Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Uzmanlık Derneği, 2015)Giriş: Clostridium difficile (C. difficile), antibiyotik ile ilişkili ishallerin en sık nedenidir. Özellikle immünsüpresyon önemli bir risk faktörü olduğu için diyare yakınması olan febril nötropenik hastalarda toksin A ... -
Hemophagocytic syndrome associated with immune reconstitution inflammatory syndrome in a patient with AIDS related Burkitt's leukemia/lymphoma.
Kanıtez, Metin; Kapmaz, Mahir; Alpay, Nilüfer; Selcukbiricik, Fatih; Çağatay, Atahan; Diz-Küçükkaya, Reyhan (Hindawi Publishing Corporation, 2014)Highly active antiretroviral therapy (HAART) has markedly decreased human immunodeficiency virus- (HIV-) related mortality and the incidence of opportunistic infections. The dramatic reduction in HIV-1 RNA and increase in ... -
Inherited disorders of platelets membrane glycoprotein disorders
Diz-Küçükkaya, Reyhan; Lopez, Jose A. (WB Saunders, 2013)Platelet membrane glycoproteins play a key role in hemostasis and thrombosis. Although disorders of platelet membrane glycoproteins are rare, their effects on the lives of those affected are very important. Severe deficiencies ... -
Inherited platelet disorders including Glanzmann thrombasthenia and Bernard-Soulier syndrome
Diz-Küçükkaya, Reyhan (American Society of Hematology, 2013)Inherited platelet disorders (IPDs) are a heterogeneous group of diseases affecting platelet production, morphology, and function. The degree of thrombocytopenia and functional abnormality of platelets determines the ... -
Lupus anticoagulant, thrombosis, and death
Diz-Küçükkaya, Reyhan (American Society of Hematology, 2015)A 32-year-old woman was referred to the hematology clinic after she was found to have persistently positive LA tests. In such a case, 3 distinct scenarios may prompt very different responses by the hematologist. In scenario ... -
MPL W515L/K mutations in chronic myeloproliferative neoplasms
Akpınar, Timur Selçuk; Hançer, Veysel Sabri; Nalçacı, Meliha; Diz-Küçükkaya, Reyhan (Galenos Yayınevi, 2013)The MPL gene encodes the thrombopoietin receptor. Recently MPL mutations (MPL W515L or MPL W515K) were described in patients with essential thrombocythemia (ET) and primary (idiopathic) myelofibrosis (PMF). The prevalence ... -
Quinolone resistance of gram negative bacteria from the patients with malignancies and relationship with prophylaxis
Fluoroquinolones are the most commonly used antibiotics for the treatment and prophylaxis of patients with malignancies. But resistance development is a big problem.With the aim of identifying the epidemiological data about ... -
The relationship between P-Selectin polymorphisms and thrombosis in antiphospholipid syndrome: A pilot case-control study
Alpay, Nilüfer; Hançer, Veysel Sabri; Erer, Burak; İnanç, Murat; Diz-Küçükkaya, Reyhan (Galenos Yayınevi, 2014)Objective: The selectins are cell adhesion molecules that mediate the interactions among leukocytes, activated platelets, and endothelial cells. We aimed to investigate whether P-selectin polymorphisms are associated with ...