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Analysis of Systemic Sclerosis-associated Genes in a Turkish Population

dc.contributor.authorDavid Carmona, F.
dc.contributor.authorOnat, Ahmet Mesut
dc.contributor.authorFernandez-Aranguren, Tamara
dc.contributor.authorSerrano-Fernandez, Alberto
dc.contributor.authorRobledo, Gema
dc.contributor.authorDireskeneli, Haner
dc.contributor.authorMartin, Javier
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T15:57:09Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T15:57:09Z
dc.date.issued2016
dc.identifier.issn0315-162X
dc.identifier.issn1499-2752
dc.identifier.urihttps://dx.doi.org/10.3899/jrheum.160045
dc.identifier.urihttp://hdl.handle.net/11446/2462
dc.descriptionWOS: 000380882000017en_US
dc.descriptionPubMed ID: 27134258en_US
dc.description.abstractObjective. To evaluate the genetic background of systemic sclerosis ( SSc) in the Turkish population. Methods. There were 354 cases and 718 unaffected controls from Turkey genotyped for the most relevant SSc genetic markers ( IRF5-rs10488631, STAT4-rs3821236, CD247-rs2056626, DNASE1L3-rs35677470, IL12A-rs77583790, and ATG5-rs9373839). Association tests were conducted to identify possible associations. Results. Except for ATG5, all the analyzed genes showed either significant associations ( IRF5: p = 1.32E-05, OR 1.76; CD247: p = 2.20E-03, OR 0.75) or trends of association ( STAT4: p = 0.066, OR 1.21; IL12A: p = 0.079, OR 4.07; DNASE1L3: p = 0.097, OR 1.41) with the overall disease or with specific phenotypes. Conclusion. The genetic component of SSc seems to be similar between Turks and Europeans.en_US
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness [SAF2012-34435]; Junta de Andalucia [BIO-1395]; RETICS (Networks for Cooperative Research in Health) Program of Instituto de Salud Carlos III [RD12/0009/0004]; "Ramon y Cajal" program of the Spanish Ministry of Economy and Competitivenessen_US
dc.description.sponsorshipSupported by SAF2012-34435 from the Spanish Ministry of Economy and Competitiveness, BIO-1395 from Junta de Andalucia, and RD12/0009/0004 from the RETICS (Networks for Cooperative Research in Health) Program of Instituto de Salud Carlos III. FDC was supported by the "Ramon y Cajal" program of the Spanish Ministry of Economy and Competitiveness.en_US
dc.language.isoengen_US
dc.publisherJ RHEUMATOL PUBL COen_US
dc.identifier.doi10.3899/jrheum.160045en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSYSTEMIC SCLEROSISen_US
dc.subjectGENETICSen_US
dc.subjectTURKEYen_US
dc.titleAnalysis of Systemic Sclerosis-associated Genes in a Turkish Populationen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF RHEUMATOLOGYen_US
dc.departmentDBÜen_US
dc.identifier.issue7en_US
dc.identifier.volume43en_US
dc.identifier.startpage1376en_US
dc.identifier.endpage1379en_US
dc.contributor.authorID0000-0002-2202-0622en_US
dc.contributor.authorID0000-0002-1427-7639en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[David Carmona, F. -- Fernandez-Aranguren, Tamara -- Serrano-Fernandez, Alberto -- Robledo, Gema -- Martin, Javier] PTS Granada, Inst Parasitol & Biomed Lopez Neyra, IPBLN CSIC, Granada, Spain -- [Onat, Ahmet Mesut] Gaziantep Univ, Dept Rheumatol, Gaziantep, Turkey -- [Direskeneli, Haner] Marmara Univ, Sch Med, Div Rheumatol, Istanbul, Turkey -- [Yavuz, Sule] Istanbul Bilim Univ, Dept Rheumatol, Istanbul, Turkey -- [Sawalha, Amr H.] Univ Michigan, Dept Internal Med, Div Rheumatol, Ann Arbor, MI 48109 USA -- [Sawalha, Amr H.] Univ Michigan, Ctr Computat Med & Bioinformat, Ann Arbor, MI 48109 USAen_US


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