Response rate of initial conventional treatments, disease course, and related factors of patients with adult-onset Still's disease: Data from a large multicenter cohort
Erişim
info:eu-repo/semantics/closedAccessTarih
2016Yazar
Kalyoncu, UmutSolmaz, Dilek
Emmungil, Hakan
Yazici, Ayten
Kasifoglu, Timucin
Kimyon, Gezmis
Pay, Salih
Üst veri
Tüm öğe kaydını gösterÖzet
Background: Adult-onset Still's disease (AOSD) is a rare condition, and treatment choices are frequently dependent on expert opinions. The objectives of the present study were to assess treatment modalities, disease course, and the factors influencing the outcome of patients with AOSD. Methods: A multicenter study was used to reach sufficient patient numbers. The diagnosis of AOSD was based on the Yamaguchi criteria. The data collected included patient age, gender, age at the time of diagnosis, delay time for the diagnosis, typical AOSD rash, arthralgia, arthritis, myalgia, sore throat, lymphadenopathy, hepatomegaly, splenomegaly, pleuritic, pericarditis, and other rare findings. The laboratory findings of the patients were also recorded. The drugs initiated after the establishment of a diagnosis and the induction of remission with the first treatment was recorded. Disease patterns and related factors were also investigated. A multivariate analysis was performed to assess the factors related to remission. Results: The initial data of 356 patients (210 females; 59%) from 19 centers were evaluated. The median age at onset was 32 (16-88) years, and the median follow-up time was 22 months (0-180). Fever (95.8%), arthralgia (94.9%), typical AOSD rash (66.9%), arthritis (64.6%), sore throat (63.5%), and myalgia (52.8%) were the most frequent clinical features. It was found that 254 of the 306 patients (83.0%) displayed remission with the initial treatment, including corticosteroids plus methotrexate with or without other disease-modifying antirheumatic drugs. The multivariate analysis revealed that the male sex, delayed diagnosis of more than 6 months, failure to achieve remission with initial treatment, and arthritis involving wrist/elbow joints were related to the chronic disease course. Conclusion: Induction of remission with initial treatment was achieved in the majority of AOSD patients. Failure to achieve remission with initial treatment as well as a delayed diagnosis implicated a chronic disease course in AOSD. (C) 2016 Elsevier Ltd. All rights reserved.
Kaynak
JOURNAL OF AUTOIMMUNITYCilt
69Koleksiyonlar
İlgili Öğeler
Başlık, yazar, küratör ve konuya göre gösterilen ilgili öğeler.
-
Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats
Erdogan M.A.; Yigitturk G.; Erbas O.; Taskıran D. (Taylor and Francis Ltd., 2022)Aim: Although the most common age-related neurodegenerative disease defined by memory loss is Alzheimer's disease (AD), only symptomatic therapies are present. A complex pathway for the AD pathogenesis that includes an ... -
Lacosamide exhibits neuroprotective effects in a rat model of Parkinson's disease
Bilal B.; Kirazlar M.; Erdogan M.A.; Yigitturk G.; Erbas O. (Elsevier B.V., 2023)Background: Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder that primarily affects the motor system. Although there are several treatments available to alleviate PD symptoms, there is ... -
Autoimmune Diseases Associated with Epilepsy
Kurtuncu, Murat; Altunrende, Burcu; Demir, Gulsen Akman (KARE PUBL, 2016)Involvement of the central nervous system (CNS) during the course of systemic autoimmune diseases is not rare. Connective tissue disorders such as systemic lupus erythematosus (SLE), rheumatoid arthritis, Behcet's disease; ...