The role of nitric oxide in testicular sperm extraction

Abstract

Many conditions or events associated with male infertility are inducers of oxidative stress. Such stress conditions can cause changes in the dynamics of testicular microvascular blood flow, endocrine signaling, and germ cell apoptosis. Testicular oxidative stress appears to be a common feature in much of what underlies male infertility. In recent years, scientists have studied the role of nitric oxide (NO) in the male infertility. There are different physiological roles for NO in male reproductive system. NO is a potent vasodilator and cell signaling molecule can play its own role in amplifying testicular injury. The aim of study is to evaluate NO and oxidative stress in testicular tissue in infertile men with azoospermia cases either do not have spermatozoa or have any spermatozoa.