dc.contributor.author | Seyithanoglu, Muhammed | |
dc.contributor.author | Oner-Iyidogan, Yildiz | |
dc.contributor.author | Dogru-Abbasoglu, Semra | |
dc.contributor.author | Tanrikulu-Kucuk, Sevda | |
dc.contributor.author | Kocak, Hikmet | |
dc.contributor.author | Beyhan-Ozdas, Sule | |
dc.contributor.author | Kocak-Toker, Necla | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:57:25Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:57:25Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1381-3455 | |
dc.identifier.issn | 1744-4160 | |
dc.identifier.uri | https://dx.doi.org/10.3109/13813455.2015.1120753 | |
dc.identifier.uri | http://hdl.handle.net/11446/2513 | |
dc.description | WOS: 000373476600008 | en_US |
dc.description | PubMed ID: 26706937 | en_US |
dc.description.abstract | Effects of curcumin (turmeric) and capsaicin (red pepper) on hepatic fat accumulation and fetuin-A expression in rats fed high-fat diet (HFD) is aimed to be investigated. Male Sprague-Dawley rats received HFD (60% of total calories from fat) and 0.15g capsaicin/kg HFD and/or 1.5g curcumin/kg HFD for 16 weeks. Hepatic AMPK, p-AMPK and fetuin-A expressions were determined by western blotting, liver lipid levels were measured with colorimetric methods and serum fetuin-A, insulin, leptin and adiponectin levels were detected using commercial ELISA kits. HFD increased hepatic lipid levels, fetuin-A expression and serum leptin, insulin and fetuin-A levels. Curcumin and capsaicin treatments significantly reduced hepatic fat accumulation and leptin levels; liver fetuin-A expression was decreased significantly by the curcumin treatment. Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation. The suppression of hepatic fetuin-A expression is observed to be especially sensitive to curcumin. | en_US |
dc.description.sponsorship | Istanbul University [39642] | en_US |
dc.description.sponsorship | This work was supported by the Research Fund of Istanbul University. Project Number: 39642. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TAYLOR & FRANCIS LTD | en_US |
dc.identifier.doi | 10.3109/13813455.2015.1120753 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Fatty liver | en_US |
dc.subject | fatty diet | en_US |
dc.subject | red pepper | en_US |
dc.subject | turmeric | en_US |
dc.subject | alpha 2 Heremans-Schmid glycoprotein | en_US |
dc.title | The effect of dietary curcumin and capsaicin on hepatic fetuin-A expression and fat accumulation in rats fed on a high-fat diet | en_US |
dc.type | article | en_US |
dc.relation.journal | ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.volume | 122 | en_US |
dc.identifier.startpage | 94 | en_US |
dc.identifier.endpage | 102 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Seyithanoglu, Muhammed -- Oner-Iyidogan, Yildiz -- Dogru-Abbasoglu, Semra -- Kocak-Toker, Necla] Istanbul Univ, Istanbul Fac Med, Dept Biochem, Istanbul, Turkey -- [Tanrikulu-Kucuk, Sevda -- Kocak, Hikmet] Istanbul Bilim Univ, Fac Med, Dept Biochem, Istanbul, Turkey -- [Beyhan-Ozdas, Sule] Istanbul Bilim Univ, Fac Med, Dept Med Biol & Genet, Istanbul, Turkey | en_US |