Gelişmiş Arama

Basit öğe kaydını göster

dc.contributor.authorTekturk, Pinar
dc.contributor.authorErdogan, Ezgi Tuna
dc.contributor.authorKurt, Adnan
dc.contributor.authorKocagoncu, Ece
dc.contributor.authorKucuk, Zeynep
dc.contributor.authorKinay, Demet
dc.contributor.authorKaramursel, Sacit
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T15:57:29Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T15:57:29Z
dc.date.issued2016
dc.identifier.issn1294-9361
dc.identifier.issn1950-6945
dc.identifier.urihttps://dx.doi.org/10.1684/epd.2016.0796
dc.identifier.urihttp://hdl.handle.net/11446/2526
dc.descriptionWOS: 000371816200008en_US
dc.descriptionPubMed ID: 26842560en_US
dc.description.abstractAim. Rasmussen encephalitis is associated with severe seizures that are unresponsive to antiepileptic drugs, as well as immunosuppressants. Transcranial direct current stimulation (t-DCS) is a non-invasive and safe method tried mostly for focal epilepsies with different aetiologies. To date, there is only one published study with two case reports describing the effect of t-DCS in Rasmussen encephalitis. Our aim was to investigate the effect of t-DCS on seizures in Rasmussen encephalitis and to clarify its safety. Methods. Five patients (mean age: 19; three females), diagnosed with Rasmussen encephalitis were included in this study. Patients received first cathodal, then anodal (2 mA for 30 minutes on three consecutive days for non-sham stimulations), and finally sham stimulation with two-month intervals, respectively. Three patients received classic (DC) cathodal t-DCS whereas two patients received cathodal stimulation with amplitude modulation at 12 Hz. Afterwards, all patients received anodal stimulation with amplitude modulation at 12 Hz. In the last part of the trial, sham stimulation (a 60-second stimulation with gradually decreasing amplitude to zero in the last 15 seconds) was applied to three patients. Maximum current density was 571 mA/m(2) using 70 mm x 50 mm wet sponge electrodes with 2-mA maximum, current controlled stimulator, and maximum charge density was 1028 C/m(2) for a 30-minute stimulation period. Results. After cathodal stimulation, all but one patient had a greater than 50% decrease in seizure frequency. Two patients who received modulated cathodal t-DCS had better results. The longest positive effect lasted for one month. A second trial with modulated anodal stimulation and a third with sham stimulation were not effective. No adverse effect was reported with all types of stimulations. Conclusions. Both classic and modulated cathodal t-DCS may be suitable alternative methods for improving seizure outcome in Rasmussen encephalitis patients.en_US
dc.language.isoengen_US
dc.publisherJOHN LIBBEY EUROTEXT LTDen_US
dc.identifier.doi10.1684/epd.2016.0796en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdirect current stimulationen_US
dc.subjectRasmussen encephalitisen_US
dc.subjectepilepsyen_US
dc.titleTranscranial direct current stimulation improves seizure control in patients with Rasmussen encephalitisen_US
dc.typearticleen_US
dc.relation.journalEPILEPTIC DISORDERSen_US
dc.departmentDBÜen_US
dc.identifier.issue1en_US
dc.identifier.volume18en_US
dc.identifier.startpage58en_US
dc.identifier.endpage66en_US
dc.contributor.authorID0000-0002-7534-9392en_US
dc.contributor.authorID0000-0002-7534-9392en_US
dc.contributor.authorID0000-0002-6292-7472en_US
dc.contributor.authorID0000-0001-7715-0320en_US
dc.contributor.authorID0000-0002-6209-6912en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Tekturk, Pinar -- Yapici, Zuhal -- Baykan, Betul] Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey -- [Erdogan, Ezgi Tuna] Istanbul Bilim Univ, Dept Physiol, Istanbul, Turkey -- [Kurt, Adnan -- Kucuk, Zeynep -- Aksu, Serkan -- Karamursel, Sacit] Istanbul Univ, Istanbul Fac Med, Dept Physiol, Istanbul, Turkey -- [Kocagoncu, Ece] Univ Cambridge, Dept Psychol, Ctr Speech Language & Brain, Cambridge, England -- [Kinay, Demet] Okmeydani Educ & Res Hosp, Dept Neurol, Istanbul, Turkeyen_US


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster