dc.contributor.author | Erdogan, Firat | |
dc.contributor.author | Kulak, Kudret | |
dc.contributor.author | Ozturk, Ozmen | |
dc.contributor.author | Ipek, Ilke Ozahi | |
dc.contributor.author | Ceran, Omer | |
dc.contributor.author | Seven, Hueseyin | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:57:40Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:57:40Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2046-9047 | |
dc.identifier.issn | 2046-9055 | |
dc.identifier.uri | https://dx.doi.org/10.1179/2046905515Y.0000000051 | |
dc.identifier.uri | http://hdl.handle.net/11446/2559 | |
dc.description | WOS: 000390990500004 | en_US |
dc.description | PubMed ID: 26256936 | en_US |
dc.description.abstract | Background: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is a common disorder in children but there is little or no consensus on its optimal diagnosis and management.Objectives: To compare the outcome of different management approaches - medical therapy or tonsillectomy.Methods: The medical records of children diagnosed with PFAPA between 2008 and 2013 were retrospectively reviewed according to the modified Thomas test criteria. Patients were divided into two groups: group 1 for medical treatment - corticosteroids, a single intramuscular injection of methylprednisolone, and group 2 for surgery - tonsillectomy alone or tonsillectomy plus adenoidectomy .The course of the disease including the number and duration of episodes and the presence of remission, was documented.Results: 105 patients (30 in group 1, 75 in group 2) met the study's inclusion criteria. Groups 1 and 2 were followed up for a mean (SD) of 23.6 (11.0) and 24 (10.3) months, respectively. At the end of the follow-up period, the number of episodes was 5.8 (6.3) vs 1.8 (1.9) (P<0.01) and their duration was 2.2 (1.3) vs 1.1 (0.8) days (P=0.03), both of which were significantly lower in group 2.The need for hospitalization during this period was significantly lower for group 2 at 1.1 (2.0) vs 0.1 (0.3) (P<0.01) and the remission rate in group 2 was significantly higher than in group 1 (98.6% vs 56.6%, P<0.01).Conclusion: This study demonstrated that surgery is superior to medical treatment for PFAPA in terms of increased remission rates and a decrease in the number and duration of episodes. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TAYLOR & FRANCIS LTD | en_US |
dc.identifier.doi | 10.1179/2046905515Y.0000000051 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Medical treatment | en_US |
dc.subject | Periodic fever | en_US |
dc.subject | PFAPA syndrome | en_US |
dc.subject | Surgery | en_US |
dc.title | Surgery vs medical treatment in the management of PFAPA syndrome: a comparative trial | en_US |
dc.type | article | en_US |
dc.relation.journal | PAEDIATRICS AND INTERNATIONAL CHILD HEALTH | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.volume | 36 | en_US |
dc.identifier.startpage | 270 | en_US |
dc.identifier.endpage | 274 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Erdogan, Firat -- Ipek, Ilke Ozahi -- Ceran, Omer] Medipol Univ, Dept Pediat, Istanbul, Turkey -- [Kulak, Kudret] Bilim Univ, Dept Pediat, Istanbul, Turkey -- [Ozturk, Ozmen -- Seven, Hueseyin] Medipol Univ, Dept Otorhinolaryngol, Istanbul, Turkey | en_US |