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Octreotide protects ovary against ischemia-reperfusion injury in rats: Evaluation of histological and biochemical parameters

Date

2015

Author

Yildirim, Nuri
Yigitturk, Gurkan
Yildirim, Alkim Gulsah Sahingoz
Akdemir, Ali
Ilgen, Orkun
Yeniel, Ozgur
Erbas, Oytun

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Abstract

AimThis study investigated the efficacy of octreotide for prevention of ischemia-reperfusion injury in rat ovary. MethodsThirty-two adult female rats were included. Rats were divided into five groups: in the sham group, the abdominal wall was only opened and closed; in the torsion group, ischemia was induced for 3 h using a torsion model involving atraumatic vascular clips; in the torsion/octreotide group, rats were given 100 mu g/kg i.p. octreotide 30 min before torsion was induced; in the torsion/detorsion group, rats underwent 3 h ischemia-3 h reperfusion; in the torsion/detorsion/octreotide group, rats underwent 3 h ischemia followed by 100 mu g/kg octreotide i.p. 30 min prior to 3 h reperfusion. Ovarian tissue damage was scored on histopathology. Ovarian tissue malondialdehyde and plasma pentraxin 3 were measured biochemically. ResultsIn comparison with the sham group, both the torsion and torsion/detorsion groups had significantly higher scores for follicular degeneration, vascular congestion, edema, hemorrhage and leukocyte infiltration. Octreotide significantly decreased these scores in both groups. Ovarian malondialdehyde and plasma pentraxin 3 were significantly higher both in the torsion and torsion/detorsion groups compared with the sham group. Octreotide also decreased these levels significantly both in the torsion/octreotide and torsion/detorsion/octreotide groups. ConclusionOctreotide ameliorated the potential side-effects of ovarian ischemia-reperfusion injury in a rat model.

Source

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Volume

41

Issue

10

URI

https://dx.doi.org/10.1111/jog.12770
http://hdl.handle.net/11446/2638

Collections

  • PubMed İndeksli Yayınlar Koleksiyonu [1178]
  • WoS İndeksli Yayınlar Koleksiyonu [1717]



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