dc.contributor.author | Yildirim, Nuri | |
dc.contributor.author | Yigitturk, Gurkan | |
dc.contributor.author | Yildirim, Alkim Gulsah Sahingoz | |
dc.contributor.author | Akdemir, Ali | |
dc.contributor.author | Ilgen, Orkun | |
dc.contributor.author | Yeniel, Ozgur | |
dc.contributor.author | Erbas, Oytun | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:58:06Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:58:06Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1341-8076 | |
dc.identifier.issn | 1447-0756 | |
dc.identifier.uri | https://dx.doi.org/10.1111/jog.12770 | |
dc.identifier.uri | http://hdl.handle.net/11446/2638 | |
dc.description | WOS: 000362677500014 | en_US |
dc.description | PubMed ID: 26223286 | en_US |
dc.description.abstract | AimThis study investigated the efficacy of octreotide for prevention of ischemia-reperfusion injury in rat ovary. MethodsThirty-two adult female rats were included. Rats were divided into five groups: in the sham group, the abdominal wall was only opened and closed; in the torsion group, ischemia was induced for 3 h using a torsion model involving atraumatic vascular clips; in the torsion/octreotide group, rats were given 100 mu g/kg i.p. octreotide 30 min before torsion was induced; in the torsion/detorsion group, rats underwent 3 h ischemia-3 h reperfusion; in the torsion/detorsion/octreotide group, rats underwent 3 h ischemia followed by 100 mu g/kg octreotide i.p. 30 min prior to 3 h reperfusion. Ovarian tissue damage was scored on histopathology. Ovarian tissue malondialdehyde and plasma pentraxin 3 were measured biochemically. ResultsIn comparison with the sham group, both the torsion and torsion/detorsion groups had significantly higher scores for follicular degeneration, vascular congestion, edema, hemorrhage and leukocyte infiltration. Octreotide significantly decreased these scores in both groups. Ovarian malondialdehyde and plasma pentraxin 3 were significantly higher both in the torsion and torsion/detorsion groups compared with the sham group. Octreotide also decreased these levels significantly both in the torsion/octreotide and torsion/detorsion/octreotide groups. ConclusionOctreotide ameliorated the potential side-effects of ovarian ischemia-reperfusion injury in a rat model. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WILEY-BLACKWELL | en_US |
dc.identifier.doi | 10.1111/jog.12770 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | ischemia-reperfusion | en_US |
dc.subject | octreotide | en_US |
dc.subject | ovary | en_US |
dc.subject | rat | en_US |
dc.title | Octreotide protects ovary against ischemia-reperfusion injury in rats: Evaluation of histological and biochemical parameters | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.volume | 41 | en_US |
dc.identifier.startpage | 1591 | en_US |
dc.identifier.endpage | 1597 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Yildirim, Nuri -- Akdemir, Ali -- Ilgen, Orkun -- Yeniel, Ozgur -- Ergenoglu, Mete] Ege Univ, Dept Obstet & Gynecol, Izmir, Turkey -- [Yigitturk, Gurkan] Ege Univ, Dept Histol & Embryol, Izmir, Turkey -- [Yildirim, Alkim Gulsah Sahingoz] Ataturk Training & Res Hosp, Dept Obstet & Gynecol, Izmir, Turkey -- [Erbas, Oytun] Bilim Univ, Dept Physiol, Istanbul, Turkey | en_US |