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dc.contributor.authorCavusoglu, T.
dc.contributor.authorKaradeniz, T.
dc.contributor.authorCagiltay, E.
dc.contributor.authorKaradeniz, M.
dc.contributor.authorYigitturk, G.
dc.contributor.authorAcikgoz, E.
dc.contributor.authorErbas, O.
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T15:58:08Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T15:58:08Z
dc.date.issued2015
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646
dc.identifier.urihttps://dx.doi.org/10.1055/s-0035-1550019
dc.identifier.urihttp://hdl.handle.net/11446/2643
dc.descriptionWOS: 000361828600008en_US
dc.descriptionPubMed ID: 26011170en_US
dc.description.abstractAim: Involvement of the peripheral and autonomic nervous systems is possibly the most frequent complication of diabetes. Important risk factors included hyperglycemia, dyslipidemia, hypertension, and smoking. Angiotensin-converting-enzyme inhibitor (ACE) inhibitors should be beneficial in all vascular beds, including neuropathy and retinopathy. In this study we aimed to evaluate the effect of the angiotensin receptor blocker losartan on diabetic neuropathy in a diabetic rat model. Material and Methods: 24 male, Sprague Dawley albino mature rats were divided into 3 groups; (1) control group: No drug was administered to the remainder of rats which blood glucose levels were under 120mg/dl, (2) diabetic control: rats were given no medication, but 4ml per day of tap water was given by oral gavage, (3) losartan groups: rats were given 10mg/kg/day oral of losartan for 4 weeks. Electromyography (EMG) was applied to anesthetized rats at the end of 4(th) weekend. Then, the animals were euthanized and sciatic nerve was performed for histopathological examination. Results: Compound Muscle Action Potential (CMAP) amplitude of diabetic rats receiving the Saline in the EMG was significantly reduced when compared to the control group. Distal latency value and CMAP duration of diabetic rats receiving the saline were meaningfully increased when compared to the control group. CMAP amplitude and CMAP duration of diabetic rats receiving the Losartan treatment in the EMG were meaningfully reduced when compared to diabetic rats receiving the Saline. Perineural thickness in the rats receiving the Losartan treatment was found to be significantly reduced when compared to the group receiving the Saline. Conclusions: As a result, it has been shown in this study that perineural thickness of the Losartan treatment was significantly reduced when compared to saline receiving group, significantly increased the immunoexpression of NGF, and also provided a significantly recovery in EMG when compared to Saline receiving group.en_US
dc.language.isoengen_US
dc.publisherJOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBHen_US
dc.identifier.doi10.1055/s-0035-1550019en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmedicineen_US
dc.subjectlosartanen_US
dc.subjectdiabetesen_US
dc.subjectelectromyographyen_US
dc.subjecthistopathologicalen_US
dc.titleThe Protective Effect of Losartan on Diabetic Neuropathy in a Diabetic Rat Modelen_US
dc.typearticleen_US
dc.relation.journalEXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETESen_US
dc.departmentDBÜen_US
dc.identifier.issue8en_US
dc.identifier.volume123en_US
dc.identifier.startpage479en_US
dc.identifier.endpage484en_US
dc.contributor.authorID0000-0003-3901-4015en_US
dc.contributor.authorID0000-0002-7709-3626en_US
dc.contributor.authorID0000-0002-4016-0522en_US
dc.contributor.authorID0000-0002-4016-0522en_US
dc.contributor.authorID0000-0002-6772-3081en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Cavusoglu, T. -- Yigitturk, G. -- Acikgoz, E. -- Uyanikgil, Y.] Ege Univ, Dept Histol & Embryol, Fac Med, Izmir, Turkey -- [Cavusoglu, T. -- Uyanikgil, Y.] Ege Univ, Cord Blood Cell & Tissue Res & Applicat Ctr, Izmir, Turkey -- [Karadeniz, T.] Izmir Tepecik Training & Res Hosp, Dept Pathol, Izmir, Turkey -- [Cagiltay, E.] GATA Haydarpasa Teaching Hosp, Dept Endocrinol & Metab, Istanbul, Turkey -- [Karadeniz, M.] Sifa Univ, Fac Med, Dept Endocrinol, Izmir, Turkey -- [Ates, U.] Bilim Univ, Dept Histol & Embryol, Fac Med, Istanbul, Turkey -- [Tuglu, M. I.] Celal Bayar Univ, Fac Med, Dept Histol & Embryol, Manisa, Turkey -- [Erbas, O.] Bilim Univ, Dept Physiol, Fac Med, Istanbul, Turkeyen_US


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