dc.contributor.author | Alco, Gul | |
dc.contributor.author | Bozdogan, Atilla | |
dc.contributor.author | Selamoglu, Derya | |
dc.contributor.author | Pilanci, Kezban Nur | |
dc.contributor.author | Tuzlali, Sitki | |
dc.contributor.author | Ordu, Cetin | |
dc.contributor.author | Ozmen, Vahit | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:58:41Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:58:41Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1792-1074 | |
dc.identifier.issn | 1792-1082 | |
dc.identifier.uri | https://dx.doi.org/10.3892/ol.2015.2852 | |
dc.identifier.uri | http://hdl.handle.net/11446/2732 | |
dc.description | WOS: 000350918100005 | en_US |
dc.description.abstract | The aim of the present study was to identify the optimal Ki-67 cut-off value in breast cancer (BC) patients, and investigate the association of Ki-67 expression levels with other prognostic factors. Firstly, a retrospective search was performed to identify patients with stage I-III BC (n=462). A range of Ki-67 index values were then assigned to five groups (<10, 10-14, 15-19, 20-24 and >= 25%). The correlation between the Ki-67 index and other prognostic factors [age, tumor type, histological and nuclear grade, tumor size, multifocality, an in situ component, lymphovascular invasion (LVI), estrogen and progesterone receptor (ER/PR) expression, human epidermal growth factor receptor (HER-2) status, axillary involvement and tumor stage] were investigated in each group. The median Ki-67 value was revealed to be 20% (range, 1-95%). A young age (<= 40 years old), tumor type, size and grade, LVI, ER/PR negativity and HER-2 positivity were revealed to be associated with the Ki-67 level. Furthermore, Ki-67 was demonstrated to be negatively correlated with ER/PR expression (P<0.001), but positively correlated with tumor size (P<0.001). The multivariate analysis revealed that a Ki-67 value of >= 15% was associated with the largest number of poor prognostic factors (P=0.036). In addition, a Ki-67 value of >= 15% was identified to be statistically significant in association with certain luminal subtypes. The rate of disease-free survival was higher in patients with luminal A subtype BC (P=0.036). Following the correlation analysis for the Ki-67 index and the other prognostic factors, a Ki-67 value of >= 15% was revealed to be the optimal cut-off level for BC patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPANDIDOS PUBL LTD | en_US |
dc.identifier.doi | 10.3892/ol.2015.2852 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | breast cancer | en_US |
dc.subject | Ki-67 | en_US |
dc.subject | out-off value | en_US |
dc.subject | prognostic factors | en_US |
dc.subject | molecular subtypes | en_US |
dc.subject | age | en_US |
dc.title | Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients | en_US |
dc.type | article | en_US |
dc.relation.journal | ONCOLOGY LETTERS | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.volume | 9 | en_US |
dc.identifier.startpage | 1046 | en_US |
dc.identifier.endpage | 1054 | en_US |
dc.contributor.authorID | 0000-0002-3592-9923 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Alco, Gul -- Okkan, Sait -- Dincer, Maktav] Gayrettepe Florence Nightingale Hosp, Dept Radiat Oncol, TR-34349 Istanbul, Turkey -- [Bozdogan, Atilla] Istanbul Florence Nightingale Hosp, Dept Biostat, TR-34349 Istanbul, Turkey -- [Selamoglu, Derya -- Ozmen, Vahit] Istanbul Florence Nightingale Hosp, Dept Breast Surg, TR-34349 Istanbul, Turkey -- [Pilanci, Kezban Nur -- Ordu, Cetin -- Demir, Gokhan] Istanbul Bilim Univ, Dept Med Oncol, TR-34349 Istanbul, Turkey -- [Tuzlali, Sitki] Istanbul Florence Nightingale Hosp, Dept Pathol, TR-34349 Istanbul, Turkey -- [Igdem, Sefik] Istanbul Bilim Univ, Dept Radiat Oncol, TR-34349 Istanbul, Turkey -- [Ozmen, Vahit] Istanbul Univ, Istanbul Fac Med, Dept Gen Surg, TR-34390 Istanbul, Turkey | en_US |