dc.contributor.author | Onur, Seda Tural | |
dc.contributor.author | Sokucu, Sinem Nedime | |
dc.contributor.author | Dalar, Levent | |
dc.contributor.author | Seyhan, Ekrem Cengiz | |
dc.contributor.author | Akbas, Aysegul | |
dc.contributor.author | Altin, Sedat | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:58:43Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:58:43Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 2374-4235 | |
dc.identifier.issn | 2374-4243 | |
dc.identifier.uri | https://dx.doi.org/10.3109/00365548.2014.975278 | |
dc.identifier.uri | http://hdl.handle.net/11446/2738 | |
dc.description | WOS: 000350052900006 | en_US |
dc.description | PubMed ID: 25549699 | en_US |
dc.description.abstract | Background: The differential diagnostic utilities of the levels of soluble interleukin (IL)-12p40 and the IL-2 receptor in sera and pleural effusions were evaluated in patients with exudative pleural effusions. Methods: We enrolled a total of 120 patients with exudative pleural effusions. The clinical, radiological, and histopathological diagnoses were tuberculous pleurisy in 52, malignant pleurisy in 39, and parapneumonic effusions in 29 patients. Results: We measured serum IL-12p40 and adenosine deaminase (ADA) levels in patients with tuberculous pleurisy and in a control group treated for pleural effusion to determine if such levels were useful in the diagnosis of pleural effusion (p < 0.005). Definite microbiological or histopathological diagnoses of tuberculous pleurisy or pleural effusion were recorded, and we found that ADA and serum soluble IL-2 receptor levels aided in diagnosis (p < 0.001). The levels of ADA and soluble IL-2 in pleural effusions afforded sensitivities and specificities of 84.62% and 82.69% and of 70.59% and 80.88%, respectively. The soluble IL-2 receptor level afforded a sensitivity and specificity of 82.69% and 52.9%. IL-12p40 levels in pleural effusions and sera afforded sensitivities and specifi cities of 80.77% and 80.77% and of 60.29% and 39.71%, respectively. Conclusion: Soluble IL-2 receptor levels in patients with tuberculous pleurisy serve as markers of disease in non-endemic countries, similarly to ADA levels. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TAYLOR & FRANCIS LTD | en_US |
dc.identifier.doi | 10.3109/00365548.2014.975278 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Tuberculosis | en_US |
dc.subject | pleural effusion | en_US |
dc.subject | soluble IL-2 receptor | en_US |
dc.subject | IL-12p40 | en_US |
dc.subject | adenosine deaminase | en_US |
dc.title | Are soluble IL-2 receptor and IL-12p40 levels useful markers for diagnosis of tuberculous pleurisy? | en_US |
dc.type | article | en_US |
dc.relation.journal | INFECTIOUS DISEASES | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.volume | 47 | en_US |
dc.identifier.startpage | 150 | en_US |
dc.identifier.endpage | 155 | en_US |
dc.contributor.authorID | 0000-0001-6678-8142 | en_US |
dc.contributor.authorID | 0000-0002-9754-5474 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Onur, Seda Tural -- Sokucu, Sinem Nedime -- Akbas, Aysegul -- Altin, Sedat] Yedikule Chest Dis & Thorac Surg Training & Res H, TR-34760 Istanbul, Turkey -- [Dalar, Levent] Bilim Univ, Florence Nightangle Hosp, Istanbul, Turkey -- [Seyhan, Ekrem Cengiz] Medipol Univ Hosp, Istanbul, Turkey | en_US |