dc.contributor.author | Cabuk, Haluk | |
dc.contributor.author | Avci, Arzu | |
dc.contributor.author | Durmaz, Huseyin | |
dc.contributor.author | Cabuk, Fatmagul Kusku | |
dc.contributor.author | Ertem, Fatih | |
dc.contributor.author | Sener, I. Muhittin | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T16:02:25Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T16:02:25Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0936-8051 | |
dc.identifier.issn | 1434-3916 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s00402-014-2099-0 | |
dc.identifier.uri | http://hdl.handle.net/11446/2803 | |
dc.description | WOS: 000345282500014 | en_US |
dc.description | PubMed ID: 25362529 | en_US |
dc.description.abstract | Introduction Matrix metalloproteinases (MMPs) are involved in physiological events such as restructuring of the tissue, morphogenesis, wound healing and normal developmental process. Use of diclofenac sodium following rotator cuff repair can disrupt healing of tendon through acting on MMPs. Materials and methods Supraspinatus tendons of rats (n = 84) were detached from their insertion on humerus, and repaired to anatomic footprint. Rats were divided into study group (n = 42) and control group (n = 42). Study group received a dose of 1 mg/kg daily diclofenac sodium subcutaneously. The rats were killed at weeks 1, 3 and 6, and seven rats from each groups were included in biomechanical and immunohistological examinations. Immunohistological staining of MMP-2, MMP-3 and MMP13 were used. Results Maximum load was reduced in the study group at the end of week 1 (8.76 vs. 5.28 N) (p = 0.01). MMP-3 level was statistically significantly lower in the study group at the end of week 1. MMP-13 level and stiffness decreased towards week 6 in the study group while in the control group the level of MMP-2 decreased towards week 6. Conclusion Diclofenac has an impact on the levels of MMP-2, MMP-3 and MMP-13, which are needed for normal healing process, and it can also lead to disruption of tendon healing. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER | en_US |
dc.identifier.doi | 10.1007/s00402-014-2099-0 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Diclofenac | en_US |
dc.subject | Matriks metalloprotinase | en_US |
dc.subject | Rotator cuff | en_US |
dc.subject | Tendon healing | en_US |
dc.subject | Biomechanic | en_US |
dc.title | The effect of diclofenac on matrix metalloproteinase levels in the rotator cuff | en_US |
dc.type | article | en_US |
dc.relation.journal | ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.volume | 134 | en_US |
dc.identifier.startpage | 1739 | en_US |
dc.identifier.endpage | 1744 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Cabuk, Haluk] Okmeydani & Res Hosp, Dept Orthoped & Traumatol, Sisli, Turkey -- [Avci, Arzu] Izmir Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Med Pathol, Izmir, Turkey -- [Durmaz, Huseyin -- Sener, I. Muhittin] Izmir Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Orthoped & Traumatol, Izmir, Turkey -- [Cabuk, Fatmagul Kusku] Istanbul Bilim Univ, Dept Med Pathol, Istanbul, Turkey -- [Ertem, Fatih] Dokuz Eylul Univ, Hlth Sci Inst, Dept Biomech, Izmir, Turkey | en_US |