Evaluation of Carotid Intima- Media Thickness and Aortic Elasticity in Patients with Nondipper Hypertension

Abstract

BackgroundThe relationship between cardiovascular diseases and the diurnal blood pressure (BP) rhythm was researched in many studies. It has been demonstrated that the nondipping pattern has been associated with target organ damage and worsened cardiovascular outcomes. The aim of our study was to assess the relationship between aortic elasticity parameters and carotid intima-media thickness (CIMT) and diastolic dysfunction in terms of dipper and nondipper hypertension subtypes. MethodsA total of 60 hypertensive patients without known coronary heart disease were recruited to our study. All patients were classified as dipper or nondipper after ambulatory BP follow-up. Patients' left ventricular (LV) systolic and diastolic functions were assessed with transthoracic echocardiography. Ascending aorta diameters and CIMT were measured by ultrasonography and the elasticity parameters of aorta were calculated by using relevant formula. ResultsThere were no significant differences between the groups with respect to demographic, biochemical data, and cardiovascular risk factors. Aortic stiffness was significantly increased in nondippers, whereas aortic strain and distensibility were significantly decreased (P=0.005, P=0.005, and P=0.024, respectively). Carotid artery IMT was significantly increased in nondippers compared to dippers (P=0.013). A significant correlation was noted between CIMT and mean BP. No significant difference was detected between 2 groups in terms of LV hypertrophy and diastolic dysfunction. ConclusionIn our study, we showed that impairment of aortic elasticity parameters and increase in CIMT as a predictor of end organ damage were more often in the nondipper hypertensive patients.