dc.contributor.author | Oner-Iyidogan, Yildiz | |
dc.contributor.author | Kocak, Hikmet | |
dc.contributor.author | Seyidhanoglu, Muhammed | |
dc.contributor.author | Gurdol, Figen | |
dc.contributor.author | Gulcubuk, Ahmet | |
dc.contributor.author | Yildirim, Funda | |
dc.contributor.author | Uysal, Mujdat | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T16:02:52Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T16:02:52Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1138-7548 | |
dc.identifier.issn | 1877-8755 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s13105-013-0244-9 | |
dc.identifier.uri | http://hdl.handle.net/11446/2937 | |
dc.description | WOS: 000327064200001 | en_US |
dc.description | PubMed ID: 23430567 | en_US |
dc.description.abstract | Fetuin-A is synthesized in the liver and is secreted into the bloodstream. Clinical studies suggest involvement of fetuin-A in metabolic disorders such as visceral obesity, insulin resistance, diabetes, and fatty liver. Curcumin is extracted from the rhizome Curcuma longa and has been shown to possess potent antioxidant, anticarcinogenic, anti-inflammatory, and hypoglycemic properties. In this study, we investigated the effect of curcumin treatment on serum fetuin-A levels as well as hepatic lipids and prooxidant-antioxidant status in rats fed a high-fat diet (HFD). Male Sprague-Dawley rats were divided into six groups. Group 1 was fed control diet (10 % of total calories from fat). Groups 2 and 3 were given curcumin (100 and 400 mg/kg bw/day, respectively ) by gavage for 8 weeks and were fed control diet. Group 4 was fed with HFD (60 % of total calories from fat). Groups 5 and 6 received HFD together with the two doses of curcumin, respectively. Curcumin treatment appeared to be effective in reducing liver triglycerides and serum fetuin-A levels. These findings suggest that the reduction of fetuin-A may contribute to the beneficial effects of curcumin in the pathogenesis of obesity. | en_US |
dc.description.sponsorship | Research Fund of Istanbul University [8244] | en_US |
dc.description.sponsorship | This work was supported by the Research Fund of Istanbul University. Project number 8244. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER | en_US |
dc.identifier.doi | 10.1007/s13105-013-0244-9 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Obesity | en_US |
dc.subject | Curcumin | en_US |
dc.subject | Fetuin-A | en_US |
dc.subject | Fatty liver | en_US |
dc.subject | High-fat diet | en_US |
dc.title | Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.volume | 69 | en_US |
dc.identifier.startpage | 677 | en_US |
dc.identifier.endpage | 686 | en_US |
dc.contributor.authorID | 0000-0001-9755-8198 | en_US |
dc.contributor.authorID | 0000-0002-9722-8831 | en_US |
dc.contributor.authorID | 0000-0003-1720-9102 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Oner-Iyidogan, Yildiz -- Seyidhanoglu, Muhammed -- Gurdol, Figen -- Uysal, Mujdat] Istanbul Univ, Istanbul Fac Med, Dept Biochem, Istanbul, Turkey -- [Kocak, Hikmet] Istanbul Bilim Univ, Fac Med, Dept Biochem, Istanbul, Turkey -- [Gulcubuk, Ahmet -- Yildirim, Funda] Istanbul Univ, Fac Vet Med, Dept Pathol, Istanbul, Turkey -- [Cevik, Aydin] Istanbul Univ, Inst Expt Res & Appl Med Res, Dept Lab Anim Biol & Appl Biomed Tech, Istanbul, Turkey | en_US |