FATIGUE STRENGTH OF ANTIBIOTIC-IMPREGNATED BONE CEMENT SAMPLES ON "DAY 0" AND "DAY 15"

Abstract

Objective: In this study, we aimed to assses the maximum efficious amount of teicoplanin in a mixture of 40 g CMV3 bone cement mixture, through the fatigue strength factor calculations. Material and Method: Five different doses of teicoplanin (0 mg, 400 mg, 800 mg, 1600 mg ve 3200 mg) were added to 40 g CMV3 bone cement mixture using the third generation cementing technique, then "day 0" and "day 15" groups were formed. Samples that were obtained on day 0 and day 15, were tested through fatigue strength machine to determine the rotational compressive strengths, intake/pulling strengths and four-point bending strengths. Day 0 and day 15 samples were compared statistically according to their fatigue strength values against the varying concentrations of antibiotic mixtures while day samples served as controls. Results: The "day 15" group that had various proportions of antibiotic which release to the surrounding was' compared to "0 mg" control group. While a meaningful reduction could not be identified between 400 mg and 800 mg doses (p>0.05) meaningful (p<0.001) strength reduced was identified between 1600 and 3200 mg doses. Day 0 and day 15 groups "fatigue-treated was applied on equal terms and group 0, 400, and 800 mg of antibiotic mixed samples did not yield any meaningful resistance differences with four points test. However, there was a statistically significant difference between 1600 and 3200 mg of the samples mixed with antibiotics (p<0.0001, p<0.0002). Conclusion: From the fatigue strength aspect, we assesed that 800 mg teicoplanin, is the maximum "efficious" amount of dose that can be added to 40 g CMV3 bone cement mixture.