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Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer

dc.contributor.authorKorkmaz, Taner
dc.contributor.authorSeber, Selcuk
dc.contributor.authorOkutur, Kerem
dc.contributor.authorBasaran, Gul
dc.contributor.authorYumuk, Fulden
dc.contributor.authorDane, Faysal
dc.contributor.authorTurhal, N. Serdar
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T16:03:16Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T16:03:16Z
dc.date.issued2013
dc.identifier.issn1354-750X
dc.identifier.issn1366-5804
dc.identifier.urihttps://dx.doi.org/10.3109/1354750X.2012.738250
dc.identifier.urihttp://hdl.handle.net/11446/3042
dc.descriptionWOS: 000313677400011en_US
dc.descriptionPubMed ID: 23116493en_US
dc.description.abstractContext: TK1 found to be elevated biomarker in many solid cancers. Objectives: The study aimed to assess the prognostic significance of a serum TK1 in patients with metastatic NSCLC. Methods: The study included 48 consecutive patients, newly diagnosed with metastatic NSCLC, and 10 healthy volunteers. Serum TK1 activity determined by ELISA method. Results: Patients with a bTK1 level > 156 Du L-1 had significantly shorter survival. TK1 level showed a strong correlation with primary tumor SUVmax. Discussion and conclusion: The magnitude of maximum fluorodeoxyglucose uptake in primary tumors and the serum TK1 level in patients with metastatic NSCLC were found to be independent prognostic predictors of overall survival.en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.identifier.doi10.3109/1354750X.2012.738250en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThymidine kinase 1(TK1)en_US
dc.subjectnon small cell lung canceren_US
dc.subjectDG uptakeen_US
dc.subjectprognosisen_US
dc.titleSerum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung canceren_US
dc.typearticleen_US
dc.relation.journalBIOMARKERSen_US
dc.departmentDBÜen_US
dc.identifier.issue1en_US
dc.identifier.volume18en_US
dc.identifier.startpage88en_US
dc.identifier.endpage94en_US
dc.contributor.authorID0000-0002-5992-545Xen_US
dc.contributor.authorID0000-0001-9081-2405en_US
dc.contributor.authorID0000-0001-8650-299Xen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Korkmaz, Taner -- Seber, Selcuk -- Basaran, Gul -- Yumuk, Fulden -- Dane, Faysal -- Turhal, N. Serdar] Marmara Univ Hosp, Dept Med Oncol, Istanbul, Turkey -- [Okutur, Kerem -- Demir, Gokhan] Istanbul Bilim Univ, Dept Med Oncol, Istanbul, Turkey -- [Ones, Tunc] Marmara Univ Hosp, Dept Nucl Med, Istanbul, Turkey -- [Polat, Ozge] Marmara Univ Hosp, Dept Internal Med, Istanbul, Turkey -- [Madenci, Ozlem Cakir] Dr Lutfi Kirdar Kartal Educ & Res Hosp, Dept Biochem, Istanbul, Turkeyen_US


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