Effect of short-term interferon-beta treatment on cytokines in multiple sclerosis: Significant modulation of IL-17 and IL-23
dc.contributor.author | Kurtuncu, Murat | |
dc.contributor.author | Tuzun, Erdem | |
dc.contributor.author | Turkoglu, Recai | |
dc.contributor.author | Petek-Balci, Belgin | |
dc.contributor.author | Icoz, Sema | |
dc.contributor.author | Pehlivan, Munevver | |
dc.contributor.author | Eraksoy, Mefkure | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T16:03:36Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T16:03:36Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1043-4666 | |
dc.identifier.issn | 1096-0023 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.cyto.2012.05.004 | |
dc.identifier.uri | http://hdl.handle.net/11446/3125 | |
dc.description | WOS: 000306159200032 | en_US |
dc.description | PubMed ID: 22652415 | en_US |
dc.description.abstract | Therapeutic effect of interferon-beta (IFN-beta) treatment has been associated with modulation of the balance between Th1, Th17, Th2 and regulatory T (Treg) cells, whereas the impact of disease modifying drugs on Th9-immunity in multiple sclerosis (MS) has not been studied. To investigate the short-term effects of IFN-beta treatment on cytokines in MS, we determined serum levels of IL-17, IL-23, IL-10, IL-4, IFN-gamma, IL-9 and TGF-beta in relapsing remitting MS patients before and 2 months after IFN-beta treatment by ELISA. MS patients showed increased IL-17, IL-23 and IL-4 levels and decreased IL-9 levels as compared to healthy controls. IFN-beta treatment only reduced IL-17 and IL-23 levels, whereas the levels of other cytokines remained unchanged. IFN-beta treatment appears to exert its earliest therapeutic effect on Th17-immunity. The influence of IL-9 on MS pathogenesis needs to be further studied. (C) 2012 Elsevier Ltd. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | en_US |
dc.identifier.doi | 10.1016/j.cyto.2012.05.004 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Multiple sclerosis | en_US |
dc.subject | Cytokine | en_US |
dc.subject | Interleukins | en_US |
dc.subject | Th17 | en_US |
dc.subject | Th1 | en_US |
dc.title | Effect of short-term interferon-beta treatment on cytokines in multiple sclerosis: Significant modulation of IL-17 and IL-23 | en_US |
dc.type | article | en_US |
dc.relation.journal | CYTOKINE | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.volume | 59 | en_US |
dc.identifier.startpage | 400 | en_US |
dc.identifier.endpage | 402 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Tuzun, Erdem -- Icoz, Sema -- Pehlivan, Munevver -- Birisik, Omer -- Shugaiv, Erkingul -- Eraksoy, Mefkure] Istanbul Univ, Istanbul Fac Med, Dept Neurol, TR-34390 Istanbul, Turkey -- [Kurtuncu, Murat] Acihadem Univ, Sch Med, Dept Neurol, Istanbul, Turkey -- [Tuzun, Erdem -- Ulusoy, Canan] Istanbul Univ, Inst Expt Med, Dept Neurosci, Istanbul, Turkey -- [Turkoglu, Recai] Haydarpasa Numune Educ & Res Hosp, Dept Neurol, Istanbul, Turkey -- [Petek-Balci, Belgin] Haseki Educ & Res Ctr, Dept Neurol, Istanbul, Turkey -- [Akman-Demir, Gulsen] Istanbul Bilim Univ, Dept Neurol, Sch Med, Istanbul, Turkey | en_US |
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