dc.contributor.author | Karatug, Ayse | |
dc.contributor.author | Sacan, Ozlem | |
dc.contributor.author | Coskun, Zeynep Mine | |
dc.contributor.author | Bolkent, Sehnaz | |
dc.contributor.author | Yanardag, Refiye | |
dc.contributor.author | Turk, Neslihan | |
dc.contributor.author | Bolkent, Sema | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T16:03:51Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T16:03:51Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0196-9781 | |
dc.identifier.issn | 1873-5169 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.peptides.2011.11.003 | |
dc.identifier.uri | http://hdl.handle.net/11446/3182 | |
dc.description | WOS: 000300073100014 | en_US |
dc.description | PubMed ID: 22138721 | en_US |
dc.description.abstract | The aim of this study was to investigate (i) the cholecystokinin, somatostatin and apelin mRNA levels, (ii) the changes in levels and localization of these peptides, (iii) relation between these peptides, (iv) anti-apoptotic effects and (v) antioxidant effects of ghrelin. The rats were divided into four groups second day after birth. These groups were respectively treated with physiological saline, ghrelin (100 mu g/kg/day), streptozotocin (100 mg/kg), ghrelin and streptozotocin. After four weeks, small intestine and blood samples were taken from rats. Cholecystokinin mRNA and peptide, somatostatin mRNA, release to duodenal lumen of apelin peptide and apelin mRNA signals decreased in ghrelin-treated diabetic rats compared to the diabetic group. There was no statistically significant difference among the four groups for somatostatin and apelin peptides. Caspase-3 signals were not observed only in diabetic group treated with ghrelin. Caspase-8 signals were increased while PCNA signals were decreased in diabetic group given ghrelin compared to diabetic group. Small intestine CAT, SOD, GP(x) and GST activities and GSH levels were decreased and LPO, PC levels were increased in diabetic rats. Administration of ghrelin to diabetic rats caused an increase in intestinal CAT, SOD, GP(x) and GST activities and GSH levels, while PC levels decreased. As a result, we observed positive changes in diabetic rats treated with ghrelin in both microscopic and biochemical studies. We can suggest that ghrelin may be an important hormone for the treatment of diabetes. (C) 2011 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | Istanbul University [1901, UDP:12304] | en_US |
dc.description.sponsorship | This study was supported by Scientific Research Projects Coordination Unit of Istanbul University, Project No. 1901 and UDP:12304. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.identifier.doi | 10.1016/j.peptides.2011.11.003 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Ghrelin | en_US |
dc.subject | Gene expression | en_US |
dc.subject | Antioxidant system | en_US |
dc.subject | Small intestine | en_US |
dc.subject | Type 2 diabetes | en_US |
dc.title | Regulation of gene expression and biochemical changes in small intestine of newborn diabetic rats by exogenous ghrelin | en_US |
dc.type | article | en_US |
dc.relation.journal | PEPTIDES | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.volume | 33 | en_US |
dc.identifier.startpage | 101 | en_US |
dc.identifier.endpage | 108 | en_US |
dc.contributor.authorID | 0000-0001-8463-5561 | en_US |
dc.contributor.authorID | 0000-0001-6032-470X | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Karatug, Ayse -- Bolkent, Sehnaz] Istanbul Univ, Dept Biol, Fac Sci, TR-34134 Istanbul, Turkey -- [Coskun, Zeynep Mine -- Turk, Neslihan -- Bolkent, Sema] Istanbul Univ, Dept Med Biol, Cerrahpasa Fac Med, TR-34098 Istanbul, Turkey -- [Sacan, Ozlem -- Yanardag, Refiye] Istanbul Univ, Dept Chem, Fac Engn, TR-34320 Istanbul, Turkey -- [Coskun, Zeynep Mine] Istanbul Bilim Univ, Hlth Serv Vocat Sch, TR-34394 Istanbul, Turkey | en_US |