dc.description.abstract | Background/aims: Partial hepatectomy is performed for the treatment of mass lesions in the liver. Lycopene, which is a carotenoid, is present in various physiologic processes. In this study, the effects of lycopene administration in partially hepatectomized rats were evaluated by assessing various oxidant/antioxidant parameters, remnant liver histology and plasma nitric oxide levels. Methods: Thirty Wistar albino adult male rats were randomly divided into three equal groups as: Sham, Partial Hepatectomy and Lycopene-Administered + Partial Hepatectomy groups. Lycopene (4 mg/kg), which was dissolved in olive oil, was given to the rats per orally (via gavage tube) (0.1 ml) every day for 6 weeks before partial hepatectomy and for one week after partial hepatectomy. Tissue and blood samples were collected one week after partial hepatectomy. Results: Plasma malondialdehyde (p < 0.001) and nitric oxide (p < 0.05) levels in the lycopene-administered + partial hepatectomy group were significantly higher than in the partial hepatectomy group. Intraerythrocytic glutathione (p < 0.001), plasma (p < 0.001) and liver tissue Cu-Zn (p < 0.05) superoxide dismutase levels of the lycopene-administered + partial hepatectomy group were significantly lower than in the partial hepatectomy group. Conclusions:,Lycopene administration could be harmful by increasing oxidative stress after partial hepatectomy. | en_US |
dc.department-temp | [Ayan, Fadil -- Aytac, Erman] Istanbul Univ, Cerrahpasa Med Sch, Dept Gen Surg, Istanbul, Turkey -- [Saygili, Seha -- Seymen, Hakki Oktay] Istanbul Univ, Cerrahpasa Med Sch, Dept Physiol, Istanbul, Turkey -- [Genc, Habibe -- Uzun, Hafize] Istanbul Univ, Cerrahpasa Med Sch, Dept Biochem, Istanbul, Turkey -- [Karaca, Cetin] Istanbul Univ, Cerrahpasa Med Sch, Dept Expt Anim Res Lab, Istanbul, Turkey -- [Bayrak, Ibrahim] Istanbul Univ, Cerrahpasa Med Sch, Div Genet, Dept Pediat, Istanbul, Turkey -- [Salihoglu, Ziya] Istanbul Univ, Cerrahpasa Med Sch, Dept Anesthesiol, Istanbul, Turkey -- [Erdamar, Sibel] Istanbul Univ, Cerrahpasa Med Sch, Dept Pathol, Istanbul, Turkey -- [Sozer, Volkan] Yildiz Tech Univ, Dept Biochem, Istanbul, Turkey -- [Altug, Tuncay] Istanbul Bilim Univ, Sch Med, Dept Med Biol & Genet, Istanbul, Turkey -- [Seymen, Pinar] Haydarpasa Numune Res & Training Hosp, Minist Hlth, Dept Internal Med, Istanbul, Turkey | en_US |