dc.contributor.author | Baykan, Betul | |
dc.contributor.author | Altindag, Ebru | |
dc.contributor.author | Feddersen, Berend | |
dc.contributor.author | Ozel, Sevda | |
dc.contributor.author | Noachtar, Soheyl | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T16:04:05Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T16:04:05Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0013-9580 | |
dc.identifier.uri | https://dx.doi.org/10.1111/j.1528-1167.2011.03126.x | |
dc.identifier.uri | http://hdl.handle.net/11446/3229 | |
dc.description | WOS: 000293178900021 | en_US |
dc.description | PubMed ID: 21668441 | en_US |
dc.description.abstract | Purpose: Studies on seizures only with an alteration of consciousness were limited mainly to generalized epilepsy. This seizure type has been described rarely in focal epilepsy. We aimed to analyze the semiologic features of this seizure type in focal and generalized epilepsies in a blinded design. Methods: A total of 338 seizure videos in 100 patients were included exclusively by semiologic criteria. Two investigators evaluated the seizure semiology (aura, seizure duration, blinking, mild motor phenomena including automatisms, and so on) from the videos. Primarily the ictal electroencephalography (EEGs) studies and all laboratory findings were evaluated for the localization of the epileptogenic zone and delineating the syndromes, in the second step. Key Findings: Of the focal epilepsy patients (n = 57), the epileptogenic zone could be localized to the temporal (n = 20), frontal (n = 9), and parietooccipital (n = 3) regions. The most common etiology of the generalized epilepsy patients (n = 43) was presumably genetic (n = 33). The presence of aura (none in generalized epilepsy vs. 35% in focal epilepsy; p = 0.0008), lack of blinking (19.3% in focal vs 65.1% in generalized epilepsy; p = 0.01), and longer seizure duration (generalized 14.3 +/- 17.7 s vs focal 54.9 +/- 40.1 s; p < 0.0001) are significantly associated with focal epilepsy, whereas high seizure frequency (p = 0.002), family history of epilepsy (p = 0.016), and responsiveness to therapy (p = 0.004) point to generalized epilepsy with logistic regression analysis. Significance: Seizures consisting mainly of an alteration in consciousness may originate from any brain lobe in focal epilepsies and also occur in generalized epilepsies. Several semiologic and clinical features that help to differentiate between focal and generalized epilepsy should be considered in the syndrome diagnosis. | en_US |
dc.description.sponsorship | Istanbul University [910/061296] | en_US |
dc.description.sponsorship | This work and the travels of the investigators (BB and EA) were supported by the Research Fund of the Istanbul University (Project number: 910/061296). We thank our EEG technicians for their contributions in all of the three centers and especially to Nazmi Aslan and Eda Cihangirli from Kenan Tukel EEG laboratory who did an enormous work putting these 338 videos in wonderful order and ensuring the blinding of the investigators. Sevda Ozel (PhD of statistics), who works in the Department of Public Health and Statistics of Istanbul Medical Faculty, carried out the biostatistical analysis. This study was presented as a poster in the 62nd American Academy of Neurology Annual Meeting, which was held in Toronto in 10-17 April 2010. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WILEY-BLACKWELL | en_US |
dc.identifier.doi | 10.1111/j.1528-1167.2011.03126.x | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Absence | en_US |
dc.subject | Semiology | en_US |
dc.subject | Consciousness | en_US |
dc.subject | Focal epilepsy | en_US |
dc.subject | Generalized epilepsy | en_US |
dc.title | Does semiology tell us the origin of seizures consisting mainly of an alteration in consciousness? | en_US |
dc.type | article | en_US |
dc.relation.journal | EPILEPSIA | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.volume | 52 | en_US |
dc.identifier.startpage | 1459 | en_US |
dc.identifier.endpage | 1466 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Baykan, Betul] Istanbul Univ, Dept Neurol, Istanbul Fac Med, Epilepsy Ctr, TR-34390 Capa, Turkey -- [Altindag, Ebru] Istanbul Bilim Univ, Dept Neurol, Istanbul, Turkey -- [Feddersen, Berend -- Noachtar, Soheyl] Univ Munich, Dept Neurol, Epilepsy Ctr, Klinikum Grosshadern, D-8000 Munich, Germany -- [Ozel, Sevda] Istanbul Univ, Dept Publ Hlth & Stat, Istanbul Fac Med, TR-34390 Capa, Turkey | en_US |