dc.contributor.author | Oner-Iyidogan, Yildiz | |
dc.contributor.author | Gurdol, Figen | |
dc.contributor.author | Kocak, Hikmet | |
dc.contributor.author | Oner, Pernur | |
dc.contributor.author | Cetinalp-Demircan, Pinar | |
dc.contributor.author | Caliskan, Yasar | |
dc.contributor.author | Turkmen, Aydin | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T16:04:06Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T16:04:06Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1051-2276 | |
dc.identifier.issn | 1532-8503 | |
dc.identifier.uri | https://dx.doi.org/10.1053/j.jrn.2010.07.005 | |
dc.identifier.uri | http://hdl.handle.net/11446/3234 | |
dc.description | WOS: 000291719600007 | en_US |
dc.description | PubMed ID: 21193324 | en_US |
dc.description.abstract | Objective: Inflammation and loss of appetite is the most common problem in patients with chronic kidney disease (CKD). This comparative cross-sectional study aimed to characterize the changes in circulating levels of ghrelin, obestatin, leptin, all of which have an effect on food intake, and proinflammatory cytokines interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-alpha) in patients with CKD who were undergoing different treatments. Design and Setting: Study participants included 36 patients who had undergone hemodialysis (body mass index [BMI]: 22.3 +/- 4.17 kg/m(2)); 41 who had undergone peritoneal dialysis (BMI: 23.5 +/- 3.10 kg/m(2)), 30 with early stage CKD (BMI: 24.4 +/- 3.32 kg/m(2)), and 31 healthy subjects (24.3 +/- 2.14 kg/m(2)). The patients with CKD were kept under a standard diet with restricted salt, potassium, and protein intake. Intervention: Levels of leptin, acylated ghrelin, obestatin, TNF-alpha, and IL-6 were measured by commercially available enzyme-linked immunosorbent assay kits. Total nitrite/nitrate was analyzed using colorimetric assay kit. Results: Significantly high leptin levels, accompanied by low acylated ghrelin levels, were observed in patients with CKD. Maintenance dialysis did not affect these levels. TNF-alpha and IL-6 levels were significantly higher in CKD patients than in healthy subjects, the highest being in dialysis patients. Obestatin levels were relatively low in patients who had undergone hemodialysis. Conclusion: Low acyl-ghrelin levels, accompanied with high levels of TNF-alpha and IL-6 may be involved in the loss of appetite and poor nutritional status in CKD patients. (C) 2011 by the National Kidney Foundation, Inc. All rights reserved. | en_US |
dc.description.sponsorship | Istanbul University [508/05052006, BYP-1789] | en_US |
dc.description.sponsorship | This work was supported by the Research Fund of Istanbul University; project numbers 508/05052006 and BYP-1789. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | en_US |
dc.identifier.doi | 10.1053/j.jrn.2010.07.005 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.title | Appetite-regulating Hormones in Chronic Kidney Disease Patients | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF RENAL NUTRITION | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.startpage | 316 | en_US |
dc.identifier.endpage | 321 | en_US |
dc.contributor.authorID | 0000-0003-1720-9102 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Gurdol, Figen -- Oner, Pernur] Istanbul Univ, Istanbul Fac Med, Dept Biochem, TR-34093 Istanbul, Turkey -- [Oner-Iyidogan, Yildiz] Istanbul Univ, Med Serv Training Sch, Med Lab Programme, TR-34093 Istanbul, Turkey -- [Kocak, Hikmet] Istanbul Bilim Univ, Dept Biochem, Istanbul, Turkey -- [Cetinalp-Demircan, Pinar] Kocaeli Univ, Fac Med, Dept Biochem, Kocaeli, Turkey -- [Caliskan, Yasar -- Turkmen, Aydin] Istanbul Univ, Istanbul Fac Med, Dept Nephrol, TR-34093 Istanbul, Turkey -- [Kocak, Taner] Istanbul Univ, Istanbul Fac Med, Dept Urol, TR-34093 Istanbul, Turkey | en_US |