dc.contributor.author | Aksoy-Sagirli, Pinar | |
dc.contributor.author | Cakmakoglu, Bedia | |
dc.contributor.author | Isbir, Turgay | |
dc.contributor.author | Kaytan-Saglam, Esra | |
dc.contributor.author | Kizir, Ahmet | |
dc.contributor.author | Topuz, Erkan | |
dc.contributor.author | Berkkan, Hakan | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T16:04:08Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T16:04:08Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0250-7005 | |
dc.identifier.issn | 1791-7530 | |
dc.identifier.uri | http://hdl.handle.net/11446/3241 | |
dc.description | WOS: 000292631300029 | en_US |
dc.description | PubMed ID: 21737645 | en_US |
dc.description.abstract | Aim: The purpose of the present study was to investigate the possible association of paraoxonase-1 (PON1) 192/55 polymorphisms with lung cancer (LC) risk in a Turkish population. Materials and Methods: A population-based, case-control study was carried out, including 223 patients with LC and 234 controls. The frequencies of PON1 192155 genotypes were compared in patient and control groups using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: Distribution of PON1 192 R (+) genotype was found to be significantly higher in patients with LC compared to the controls (odds ratio: 1.497, 95% confidence interval: 1.034-2.166). This difference was especially noteworthy in patients with small cell carcinoma and squamous cell carcinoma. Conclusion: This is the first case-control study on the association between PON1 polymorphisms and LC susceptibility in a Turkish population. Our results suggest that PON1 192 polymorphsim is associated with an increased risk of LC in the Turkish population and may be a useful genetic marker for small cell and squamous cell carcinoma. | en_US |
dc.description.sponsorship | Istanbul University [T-561/21102004, UDP-4443/15102009] | en_US |
dc.description.sponsorship | This research was supported in part by the following grants: Istanbul University Scientific Research Projects, Project no: T-561/21102004 and UDP-4443/15102009. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | INT INST ANTICANCER RESEARCH | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Paraoxonase 1 | en_US |
dc.subject | PON1 | en_US |
dc.subject | polymorphism | en_US |
dc.subject | lung cancer risk | en_US |
dc.subject | SNP | en_US |
dc.title | Paraoxonase-1 192/55 Polymorphisms and the Risk of Lung Cancer in a Turkish Population | en_US |
dc.type | article | en_US |
dc.relation.journal | ANTICANCER RESEARCH | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.volume | 31 | en_US |
dc.identifier.startpage | 2225 | en_US |
dc.identifier.endpage | 2229 | en_US |
dc.contributor.authorID | 0000-0001-7960-9131 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Aksoy-Sagirli, Pinar] Istanbul Univ, Fac Pharm, Dept Biochem, TR-34116 Istanbul, Turkey -- [Cakmakoglu, Bedia] Istanbul Univ, Expt Med Res Inst, TR-34116 Istanbul, Turkey -- [Kaytan-Saglam, Esra -- Kizir, Ahmet -- Topuz, Erkan] Istanbul Univ, Inst Oncol, TR-34116 Istanbul, Turkey -- [Isbir, Turgay] Yeditepe Univ, Fac Med, Istanbul, Turkey -- [Berkkan, Hakan] Istanbul Bilim Univ, Fac Med, Dept Biochem, Istanbul, Turkey | en_US |