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dc.contributor.authorKocyigit-Kaymakcioglu, Bedia
dc.contributor.authorAker, Rezzan Gulhan
dc.contributor.authorTezcan, Kutluhan
dc.contributor.authorSakalli, Eren
dc.contributor.authorKetenci, Sema
dc.contributor.authorOruc-Emre, Emine Elcin
dc.contributor.authorRollas, Sevim
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T16:04:09Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T16:04:09Z
dc.date.issued2011
dc.identifier.issn1054-2523
dc.identifier.urihttps://dx.doi.org/10.1007/s00044-010-9358-6
dc.identifier.urihttp://hdl.handle.net/11446/3245
dc.descriptionWOS: 000289849900012en_US
dc.description.abstractA series of 3,5-dimethylpyrazole derivatives, structurally related to the previously described potent ameltolide analogues, were synthesized and evaluated for their anticonvulsant activity. Ten compounds were prepared by reacting the 4-amino-3,5-dimethylpyrazole with appropriate substituted carboxylic acids, benzoyl chlorides and benzaldehydes to obtain amide and imine derivatives. Initial anticonvulsant screening was performed using intraperitoneal pentylenetetrazole (PTZ) and maximal electroshock (MES) induced seizure tests in mice. Among the 10 tested compounds, N-[1-(4-methoxybenzoyl)-3,5-dimethylpyrazole-4-yl]-4-methoxybenzamide 2 and N-[1-(2,6-dichlorobenzoyl)-3,5-dimethylpyrazole-4-yl]-2,6-dichlorobenzamide 3 decreased seizure severity and the mortality rate in the PTZ test. Hence, compound 3 was tested in an animal model of absence epilepsy, Genetic Absence Epileptic Rats from Strasbourg (GAERS). There were no significant changes in the duration or number of spike-and-wave discharges in this model.en_US
dc.description.sponsorshipMarmara University Scientific Research Projects Commission (BAPKO) [SAG-BGS-270605-0132]en_US
dc.description.sponsorshipThe authors thank Marmara University Scientific Research Projects Commission (BAPKO, Project number SAG-BGS-270605-0132) for the financial support of this study and to Prof. R.W. Guillery for his valuable comments on the manuscript.en_US
dc.language.isoengen_US
dc.publisherBIRKHAUSER BOSTON INCen_US
dc.identifier.doi10.1007/s00044-010-9358-6en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject3,5-Dimethylpyrazoleen_US
dc.subjectAmideen_US
dc.subjectImineen_US
dc.subjectAnticonvulsant activityen_US
dc.titleAnticonvulsant activity of 3,5-dimethylpyrazole derivatives in animal modelsen_US
dc.typearticleen_US
dc.relation.journalMEDICINAL CHEMISTRY RESEARCHen_US
dc.departmentDBÜen_US
dc.identifier.issue5en_US
dc.identifier.volume20en_US
dc.identifier.startpage607en_US
dc.identifier.endpage614en_US
dc.contributor.authorID0000-0003-4601-7871en_US
dc.contributor.authorID0000-0003-0680-4782en_US
dc.contributor.authorID0000-0002-1519-3170en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Kocyigit-Kaymakcioglu, Bedia -- Rollas, Sevim] Marmara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34668 Istanbul, Turkey -- [Aker, Rezzan Gulhan -- Tezcan, Kutluhan -- Sakalli, Eren -- Ketenci, Sema -- Gurbanova, Ayten -- Terzioglu, Berna -- Onat, Filiz] Marmara Univ, Sch Med, Dept Pharmacol & Clin Pharmacol, TR-34668 Istanbul, Turkey -- [Oruc-Emre, Emine Elcin] Gaziantep Univ, Dept Chem, Sehitkamil, Gaziantep, Turkey -- [Akin, Demet] Istanbul Bilim Univ, Sch Med, Dept Pharmacol, Istanbul, Turkey -- [Kocyigit-Kaymakcioglu, Bedia -- Aker, Rezzan Gulhan -- Oruc-Emre, Emine Elcin -- Onat, Filiz -- Rollas, Sevim] Marmara Univ, Epilepsy Res Ctr, TR-34668 Istanbul, Turkeyen_US


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