Advanced Search

Show simple item record

dc.contributor.authorAker, Rezzan Guelhan
dc.contributor.authorTezcan, Kutluhan
dc.contributor.authorCarcak, Nihan
dc.contributor.authorSakalli, Eren
dc.contributor.authorAkin, Demet
dc.contributor.authorOnat, Filiz Yilmaz
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T16:04:42Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T16:04:42Z
dc.date.issued2010
dc.identifier.issn0920-1211
dc.identifier.issn1872-6844
dc.identifier.urihttps://dx.doi.org/10.1016/j.eplepsyres.2009.10.013
dc.identifier.urihttp://hdl.handle.net/11446/3356
dc.descriptionAlumni Conference on San Servolo Epilepsy Courses -- JUN 21-24, 2009 -- Pecs, HUNGARYen_US
dc.descriptionWOS: 000277216200003en_US
dc.descriptionPubMed ID: 19939632en_US
dc.description.abstractModels of genetic absence epilepsy are resistant to secondary generalization of focal limbic seizures. This correlates with the postnatal development of spike-and-wave discharges (SWDs), a hallmark of absence seizures arising from a cortical focus in the perioral region of somatosensory cortex. Ethosuximide injected at this site suppresses SWDs. The effect of this suppression on kindling in "Genetic Absence Epilepsy Rats from Strasbourg" (GAERS), has been compared for postnatal 30 day (PN30) rats having immature SWDs and adult (>4 months) rats having mature SWDs. Non-epileptic Wistar and GAERS rats were implanted with a basolateral amygdaloid stimulation electrode, bilateral injection cannulas into the cortical perioral focus, and cortical recording electrodes. Following recovery cortical injections of ethosuximide or saline were made and after 30 min rats were given 36 stimulations or until Racine's stage 5 seizures were produced. All Wistar rats (PN30 and adult) treated with saline or ethosuximide reached stage 5. Of GAERS given saline, 33% (PN30) and 43% (adults) were resistant to kindling; after ethosuximide pups behaved like Wistars, but adults showed a delay in kindling relative to Wistars. These findings imply that mechanisms underlying kindling resistance are related but not limited to SWD activity in animals with genetic absence epilepsy. (C) 2009 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipInt Sch Neurol Scien_US
dc.language.isoengen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.isversionof10.1016/j.eplepsyres.2009.10.013en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCortical focusen_US
dc.subjectLimbic epilepsyen_US
dc.subjectCircuitryen_US
dc.subjectAmygdalaen_US
dc.subjectTemporal lobeen_US
dc.subjectSWDen_US
dc.titleLocalized cortical injections of ethosuximide suppress spike-and-wave activity and reduce the resistance to kindling in genetic absence epilepsy rats (GAERS)en_US
dc.typearticleen_US
dc.relation.journalEPILEPSY RESEARCHen_US
dc.contributor.departmentDBÜen_US
dc.identifier.issue1en_US
dc.identifier.volume89en_US
dc.identifier.startpage7en_US
dc.identifier.endpage16en_US
dc.contributor.authorID0000-0002-1519-3170en_US
dc.contributor.authorID0000-0003-0680-4782en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record