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dc.contributor.authorAksu, Neslihan
dc.contributor.authorSeyahi, Aksel
dc.contributor.authorAksu, Taner
dc.contributor.authorOeztuerk, Cagatay
dc.contributor.authorDervisoglu, Serguelen
dc.contributor.authorHiz, Veli Muzaffer Murat
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T16:05:15Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T16:05:15Z
dc.date.issued2008
dc.identifier.issn0936-8051
dc.identifier.urihttps://dx.doi.org/10.1007/s00402-008-0664-0
dc.identifier.urihttp://hdl.handle.net/11446/3456
dc.descriptionWOS: 000259456100028en_US
dc.descriptionPubMed ID: 18560854en_US
dc.description.abstractIntroduction Chemical and physical effects of cementation cause radiographic and histological changes at bone-cement interface. These changes can be of interest in the assessment of the residual lesions and subsequent recurrences after local resection and cementation of local aggressive tumours. Aim The aim of the study was to evaluate the evolution and determine the stages of the changes that occur at the bone-cement interface after cementation of cavitary lesions. Materials and methods We operated on 16 hind legs of 8 sheep (Ovies Aries) under general anaesthesia (Xylasin HCl, Ketamin HCl and Forane). A bone cavity of 12 cm(3) was produced by curettage of the distal femoral condyle and was filled with cement. Control radiographs were taken at 2 days; 3, 6 and 12 weeks, and again at 6 months. One sheep each time was killed after second day and sixth month and two sheep each time after the third, sixth and 12th week and the specimens underwent pathological examination. Results After the first 3 weeks, a reactive fibrous membrane was detected on pathological examinations. This membrane consisted of granulation tissue, necrotic bone and bone marrow, which were replaced gradually by fibrous tissue. The radiographic revelation of this fibrous membrane was a radiolucent zone of 0.5-1.5 mm at 3 weeks. A Sclerotic rim appeared around this radiolucent zone at 6 weeks. With new bone formation the fibrous membrane disappeared at 3 months. This was seen on radiographs as the replacement of the radiolucent zone by a sclerotic ring of 0.5-2 mm. This sclerotic ring disappeared at 6 months, when a diffuse sclerosis and cortical bone thickening was detected on radiographs. Discussion According to our findings we suggest to consider the pathological processes at the bone-cement interface in 3 phases: (1) Reactive phase (first 3 weeks); (2) Resorption phase (3-6 weeks), and (3) Formation phase (6 weeks to 6 months). We have distinguished five different radiographic stages: Stage 1-Early stage with no apparent zone (first 3 weeks); Stage 2-Radiolucent zone (3-6 weeks); Stage 3-Radiolucent zone with a sclerotic rime (6 weeks to 3 months); Stage 4-sclerotic ring (after 3 months) and Stage 5-Diffuse cortical thickening (after 6 months). Determining the phases of tissue reaction after cementation and its radiographic revelation will ease the diagnosis of residual lesions and subsequent recurrences after local resection and cementation of local aggressive tumors.en_US
dc.description.sponsorshipResearch Fund of Istanbul University [1357/280799]en_US
dc.description.sponsorshipThis experiment was supported by Research Fund of Istanbul University (Project number: 1357/280799).en_US
dc.language.isoengen_US
dc.publisherSPRINGERen_US
dc.relation.isversionof10.1007/s00402-008-0664-0en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpolymethylmetacrylateen_US
dc.subjectbone cementen_US
dc.subjectinterfaceen_US
dc.subjectnecrosisen_US
dc.subjectradiographic stagesen_US
dc.titleRadiographic and pathological stages of the changes at the bone-cement interface: an in-vivo experimental studyen_US
dc.typearticleen_US
dc.relation.journalARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERYen_US
dc.contributor.departmentDBÜen_US
dc.identifier.issue10en_US
dc.identifier.volume128en_US
dc.identifier.startpage1187en_US
dc.identifier.endpage1191en_US
dc.contributor.authorID0000-0003-3133-206Xen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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