Yayıncı "NATURE PUBLISHING GROUP" PubMed İndeksli Yayınlar Koleksiyonu için listeleme
Toplam kayıt 13, listelenen: 1-13
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Ampullary carcinoma is often of mixed or hybrid histologic type: an analysis of reproducibility and clinical relevance of classification as pancreatobiliary versus intestinal in 232 cases
(NATURE PUBLISHING GROUP, 2016)Histologic classification of ampullary carcinomas as intestinal versus pancreatobiliary is rapidly becoming a part of management algorithms, with immunohistochemical classification schemes also being devised using this ... -
Biallelic loss of human CTNNA2, encoding alpha N-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration
(NATURE PUBLISHING GROUP, 2018)Neuronal migration defects, including pachygyria, are among the most severe developmental brain defects in humans. Here, we identify biallelic truncating mutations in CTNNA2, encoding alpha N-catenin, in patients with a ... -
Biallelic mutations in the 3 ' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing
(NATURE PUBLISHING GROUP, 2017)Deadenylases are best known for degrading the poly(A) tail during mRNA decay. The deadenylase family has expanded throughout evolution and, in mammals, consists of 12 Mg2+-dependent 3'-end RNases with substrate specificity ... -
Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly
(NATURE PUBLISHING GROUP, 2017)Recessive mutations in WD repeat domain 62 (WDR62) cause microcephaly and a wide spectrum of severe brain malformations. Disruption of the mouse ortholog results in microcephaly underlain by reduced proliferation of ... -
Dual effects of testosterone in Behcet's disease: implications for a role in disease pathogenesis
(NATURE PUBLISHING GROUP, 2016)Behcet's disease (BD) exhibits more severe disease course and higher mortality among male patients. However, underlying mechanisms of gender differences in clinical manifestations and disease severity are unclear. The aim ... -
The effect of intravitreal bevacizumab (avastin) administration on systemic hypertension
(NATURE PUBLISHING GROUP, 2009)Aims To determine the short-term effect of intravitreal bevacizumab administration on systemic blood pressure levels of patients and to evaluate the safety of the drug in these patients. Methods Study population was divided ... -
Exonic duplication CNV of NDRG1 associated with autosomal-recessive HMSN-Lom/CMT4D
(NATURE PUBLISHING GROUP, 2014)Purpose: Copy-number variations as a mutational mechanism contribute significantly to human disease. Approximately one-half of the patients with Charcot-Marie-Tooth (CMT) disease have a 1.4Mb duplication copy-number variation ... -
Incidence and management of acute endophthalmitis after intravitreal bevacizumab (Avastin) injection
(NATURE PUBLISHING GROUP, 2009)Introduction The aim of this study was to report the incidence and management of acute endophthalmitis after intravitreal injection of Avastin (bevacizumab), and visual acuity outcomes of three eyes of three patients who ... -
An observational study to evaluate factors responsible and actions taken for hypertensive patients who are not at blood pressure goal: i-target Goal Study
(NATURE PUBLISHING GROUP, 2012)To evaluate the percentage of hypertensive patients who could achieve target blood pressure (TBP) according to the guidelines in the context of recommended measures and the factors responsible for failure. A total of 589 ... -
A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP
(NATURE PUBLISHING GROUP, 2016)The fat mass and obesity associated (FTO) gene has previously been associated with a variety of diseases and conditions, notably obesity, acute coronary syndrome and metabolic syndrome. Reports describing mutations in FTO ... -
Resveratrol treatment may preserve the erectile function after radiotherapy by restoring antioxidant defence mechanisms, SIRT1 and NOS protein expressions
(NATURE PUBLISHING GROUP, 2018)Radiotherapy (RT) for prostate cancer (PC) can cause erectile dysfunction (ED) by damaging neurovascular structures with oxidative stress. In this study, we evaluated the effects of resveratrol, an antioxidant, on post-RT ... -
Sarcopenia assessment project in the nursing homes in Turkey
(NATURE PUBLISHING GROUP, 2014)BACKGROUND/OBJECTIVES: Sarcopenia and sarcopenic obesity (SO) are geriatric syndromes leading to physical disability, poor quality of life and death. The aim of this study was to investigate the prevalence of sarcopenia ... -
Short-term effects of intravitreal ranibizumab and bevacizumab administration on 24-h ambulatory blood pressure monitoring recordings in normotensive patients with age-related macular degeneration
(NATURE PUBLISHING GROUP, 2017)Purpose To evaluate effects of intravitreal ranibizumab and bevacizumab administration on ambulatory blood pressure monitoring (ABPM) recordings in normotensive patients with age-related macular degeneration (AMD). Patients ...