Search
Now showing items 11-20 of 24
Beneficial effects of sennoside B on pentylenetetrazole-induced seizures in rats
(SAGE Publications Ltd, 2023)
Background: Epilepsy is a common disorder affecting approximately 50 million people worldwide. Oxidative stress is known to play an important role in the pathophysiology of diseases, including epilepsy. In this study, we ...
Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis
(Turkish Association of Trauma and Emergency Surgery, 2022)
BACKGROUND: Acute respiratory distress syndrome is a devastating complication of severe sepsis. Preclinical models suggest that direct lung injury begins with attack to the lung epithelium, but indirect lung injury results ...
Lacosamide exhibits neuroprotective effects in a rat model of Parkinson's disease
(Elsevier B.V., 2023)
Background: Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder that primarily affects the motor system. Although there are several treatments available to alleviate PD symptoms, there is ...
Sulfasalazine prevents lung injury due to intra-abdominal sepsis in rats: possible role of Nrf2 and angiopoietin-2
(Assoc Bras Divulg Cientifica, 2023)
This study aimed to investigate the effect of sulfasalazine in preventing and treating intra-abdominal sepsis-induced acute respiratory distress syndrome (ARDS) in a rat model. Forty male Wistar albino rats were used. The ...
Oxytocin mitigates peripheral nerve damage via Nrf2 and irisin pathway
(Verduci Editore s.r.l, 2023)
OBJECTIVE: Peripheral nerve injuries present challenges in achieving full functional restoration, necessitating effective therapeutic strategies. Oxytocin, known for its neuroprotective and anti-inflammatory properties, ...
Effect of chronic alcohol consumption on myocardial apoptosis in the rat model of isoproterenol-induced myocardial injury and investigation on the cardioprotective role of calpain inhibitor 1
(Taylor and Francis Ltd., 2022)
We investigated the presence of myocardial apoptosis on isoproterenol (ISO)-induced myocardial injury (MI) after long-term high dose alcohol consumption and examined the antiapoptotic role of calpain inhibitor 1. Male ...
The Efficacy of Hydrodilatation for the Prevention of Vasospasm following Microsurgical Anastomosis
(Thieme Medical Publishers, Inc., 2022)
Background âVasospasm is a major problem following microsurgical reconstruction which can result in the partial or complete loss of the flap tissue. The aim of this study was to investigate the efficiency of hydrodilatation ...
Demonstration of ameliorating effect of papaverine in sepsis-induced acute lung injury on rat model through radiology and histology
(Turkish Association of Trauma and Emergency Surgery, 2023)
BACKGROUND: Our target was to show the role of high mobility group box-1/receptor for (HMGB1/RAGE) interaction in feces intraperitoneal injection procedure (FIP)-induced acute lung injury (ALI) pathophysiology, to investigate ...
Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats
(Taylor and Francis Ltd., 2022)
Aim: Although the most common age-related neurodegenerative disease defined by memory loss is Alzheimer's disease (AD), only symptomatic therapies are present. A complex pathway for the AD pathogenesis that includes an ...
Hepatic insulin synthesis increases in rat models of diabetes mellitus type 1 and 2 differently
(Public Library of Science, 2023)
Insulin-positive (+) cells (IPCs), detected in multiple organs, are of great interest as a probable alternative to ameliorate pancreatic beta-cells dysfunction and insulin deficiency in diabetes. Liver is a potential source ...