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Toplam kayıt 33, listelenen: 21-30
An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
(Hindawi Ltd, 2021)
Purpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. ...
Effect of Lipid Emulsion on the Improvement of Renal Damage in Colist-in-Induced Nephrotoxicity
(Bentham Science Publ, 2021)
Background: Colistin utilization has gradually increased worldwide with the rising of multidrug-resistant (MDR) gram-negative bacilli despite its nephrotoxicity. Lipid emulsion (LE) is widely used for the toxic overdose ...
Protective effects of dichloroacetic acid on endometrial injury and ovarian reserve in an experimental rat model of diabetes mellitus
(Wiley, 2021)
Aim To study (1) ovarian and endometrial damage caused by the hyperglycemia and (2) the effects of dichloroacetic acid (DCA) on follicular reserve and endometrial damage in streptozocin induced diabetic rats. Methods This ...
Exposure to hypertonic solutions during pregnancy induces autism-like behaviors via the NFAT-5 pathway in offspring in a rat model
(Pergamon-Elsevier Science Ltd, 2021)
Objectives: to investigate the effects of hyperosmolar state (HS) on immune response and inflammation via the NFAT5 pathway and examine whether immune-mediated conditions trigger autism-like behavior in offspring. Methods: ...
The Restorative Effect of Gallic Acid on the Experimental Sciatic Nerve Damage Model
(Korean Neurosurgical Soc, 2021)
Objective : Peripheral nerve injuries occur mostly as a result of mechanical trauma. Due to the microvascular deterioration in peripheral nerve damage, it becomes challenging to remove free oxygen radicals. Gallic acid is ...
The neuro-restorative effect of adipose-derived mesenchymal stem cell transplantation on a mouse model of diabetic neuropathy
(Taylor & Francis Ltd, 2021)
Diabetic neuropathy (DN) is the most common degenerative complication associated with Diabetes Mellitus. Despite widespread awareness about DN, the only effective treatments are blood glucose control and pain management. ...
Vitamin C (Ascorbic acid) protects from neuropathy caused by cisplatin, through enhanced heat shock protein-70 and reduced oxidant effect
(Assoc Medica Brasileira, 2022)
OBJECTIVE: We aimed to determine whether vitamin C has a protective effect on cisplatin-induced neuropathy in rats.METHODS: In total, 24 rats were included in the study of which 8 rats (no drug administered) were categorized ...
Antifibrotic preventive effect of polyethylene glycol (PEG) 3350 in methotrexate-induced hepatoxicity model
(Acta Cirurgica Brasileira, 2022)
Purpose: Liver damage caused by drugs and other chemicals accounts for about 5% of all cases. Methotrexate (MTX), a folic acid analogue, is a first-line synthetic antimetabolite agent routinely used in the treatment of ...
The effect of Madopar on absence-like seizures in WAG/Rij rats
(Nencki Inst Experimental Biology, 2022)
The aim of this study was to investigate the effect of Madopar on the absence seizures and the anxiety-like behavior (assessed using the open field test) in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Twenty-eight male ...
Demonstration of ameliorating effect of vardenafil through its anti-inflammatory and neuroprotective properties in autism spectrum disorder induced by propionic acid on rat model
(Taylor & Francis Ltd, 2022)
Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex etiology. In this study, we aimed to determine the ameliorating effects of vardenafil in the ASD rat model induced by propionic acid ...