Changes in serum paraoxonase activity, calcium and lipid profiles in pre-eclampsia, a preliminary study [Preeklampsi?'de paraoksanaz akti?vi?tesi?, kalsi?yum ve li?pi?d profi?lleri?ni?n değerlendi?ri?lmesi?, ön çalifima]

Abstract

Objective: To investigate serum paraoxonase (PON1) activity, serum calcium, and lipid profiles in pre-eclampsia. Material and methods: Serum PON1 activity, calcium, and lipid profiles were measured in a cohort of 45 women with normal pregnancies (11 patients) and pre-eclampsia (34 patients). Results: Triglyceride, total cholesterol, and LDL cholesterol concentrations were significantly increased in women with pre-eclampsia, compared with women with normal pregnancies. Serum HDL cholesterol, PON1, and calcium levels in pre-eclamptic patients were significantly lower than those in healthy pregnant women. Conclusion: the significant decrease of PON1 activity in pre-eclampsia is related to lipid profiles and calcium.