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Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities

dc.contributor.authorJohnson, Sindhu R.
dc.contributor.authorBrinks, Ralph
dc.contributor.authorCostenbader, Karen H.
dc.contributor.authorDaikh, David
dc.contributor.authorMosca, Marta
dc.contributor.authorRamsey-Goldman, Rosalind
dc.contributor.authorAringer, Martin
dc.date.accessioned2020-12-02T18:01:23Z
dc.date.available2020-12-02T18:01:23Z
dc.date.issued2020
dc.identifier.issn0003-4967
dc.identifier.issn1468-2060
dc.identifier.urihttps://doi.org/10.1136/annrheumdis-2020-217162
dc.identifier.urihttp://hdl.handle.net/11446/3598
dc.descriptionIzmirly, Peter/0000-0001-5445-2182; Johnson, Sindhu R./0000-0003-0591-2976; Doria, Andrea/0000-0003-0548-4983en_US
dc.descriptionWOS: 000573924600031en_US
dc.descriptionPubMed: 32816709en_US
dc.description.abstractObjectives the European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 Classification Criteria for systemic lupus erythematosus (SLE) have been validated with high sensitivity and specificity. We evaluated the performance of the new criteria with regard to disease duration, sex and race/ethnicity, and compared its performance against the Systemic Lupus International Collaborating Clinics (SLICC) 2012 and ACR 1982/1997 criteria. Methods Twenty-one SLE centres from 16 countries submitted SLE cases and mimicking controls to form the validation cohort. the sensitivity and specificity of the EULAR/ACR 2019, SLICC 2012 and ACR 1982/1997 criteria were evaluated. Results the cohort consisted of female (n=1098), male (n=172), Asian (n=118), black (n=68), Hispanic (n=124) and white (n=941) patients; with an SLE duration of 1 to <3 years (n=196) and >= 5 years (n=879). Among patients with 1 to <3 years disease duration, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 81%). the EULAR/ACR criteria performed well in men (sensitivity 93%, specificity 96%) and women (sensitivity 97%, specificity 94%). Among women, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 83%) and better specificity than the SLICC criteria (94% vs 82%). Among white patients, the EULAR/ACR criteria had better sensitivity than the ACR criteria (95% vs 83%) and better specificity than the SLICC criteria (94% vs 83%). the EULAR/ACR criteria performed well among black patients (sensitivity of 98%, specificity 100%), and had better sensitivity than the ACR criteria among Hispanic patients (100% vs 86%) and Asian patients (97% vs 77%). Conclusions the EULAR/ACR 2019 criteria perform well among patients with early disease, men, women, white, black, Hispanic and Asian patients. These criteria have superior sensitivity than the ACR criteria and/or superior specificity than the SLICC criteria across many subgroups.en_US
dc.description.sponsorshipEuropean League Against Rheumatism; American College of Rheumatology; Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Healthen_US
dc.description.sponsorshipThis body of work was jointly supported by the European League Against Rheumatism and the American College of Rheumatology. This research was supported (in part) by the Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health.en_US
dc.language.isoengen_US
dc.publisherBmj Publishing Groupen_US
dc.identifier.doi10.1136/annrheumdis-2020-217162en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsystemic lupus erythematosusen_US
dc.subjectepidemiologyen_US
dc.subjectlupus nephritisen_US
dc.subjectoutcomes researchen_US
dc.titlePerformance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicitiesen_US
dc.typearticleen_US
dc.relation.journalAnnals of the Rheumatic Diseasesen_US
dc.departmentDBÜen_US
dc.identifier.issue10en_US
dc.identifier.volume79en_US
dc.identifier.startpage1333en_US
dc.identifier.endpage1339en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Johnson, Sindhu R.] Univ Toronto, Toronto Western Hosp, Dept Med, Div Rheumatol,Mt Sinai Hosp, Toronto, ON, Canada; [Johnson, Sindhu R.] Univ Toronto, Inst Hlth Policy Management & Evaulat, Toronto, ON, Canada; [Brinks, Ralph] Heinrich Heine Univ Duesseldorf, Policlin & Hiller Res Unit Rheumatol, Dusseldorf, Germany; [Costenbader, Karen H.] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Rheumatol Inflammat & Immun, Boston, MA 02115 USA; [Costenbader, Karen H.; Massarotti, Elena; Tedeschi, Sara K.] Harvard Med Sch, Rheumatol, Boston, MA 02115 USA; [Daikh, David] UCSF Med Ctr, Med Rheumatol, San Francisco, CA USA; [Mosca, Marta] Univ Pisa, Rheumatol Unit, Pisa, Italy; [Ramsey-Goldman, Rosalind] Northwestern Univ, Feinberg Sch Med, Med Rheumatol, Chicago, IL 60611 USA; [Smolen, Josef S.; Stummvoll, Georg H.] Med Univ Vienna, Rheumatol, Vienna, Austria; [Wofsy, David] Univ Calif San Francisco, Div Rheumatol, Russell Engleman Rheumatol Res Ctr, San Francisco, CA 94143 USA; [Boumpas, Dimitrios T.] Natl & Kapodestrian Univ Athens, Med, Athens, Greece; [Boumpas, Dimitrios T.] Acad Athens, Biomed Res Fdn, Athens, Greece; [Boumpas, Dimitrios T.] Univ Cyprus, Rheumatol, Med Sch, Nicosia, Cyprus; [Kamen, Diane L.] Med Univ South Carolina, Rheumatol, Charleston, SC 29425 USA; [Jayne, David] Univ Cambridge, Med, Cambridge, England; [Cervera, R.] Univ Barcelona, Hosp Clin, Autoimmune Dis, Barcelona, Catalonia, Spain; [Costedoat-Chalumeau, Nathalie] Hosp Cochin, Internal Med, Paris, Ilede France, France; [Costedoat-Chalumeau, Nathalie] Univ Paris 05, Ctr Epidemiol & Stat, INSERM, Sorbonne Paris Cite,U 1153, Paris, France; [Diamond, Betty] Feinstein Inst Med Res, Autoimmune & Musculoskeletal, Manhasset, NY USA; [Gladman, Dafna D.] Univ Toronto, Med, Toronto, ON, Canada; [Gladman, Dafna D.] Toronto Western Hosp, Med, Toronto, ON, Canada; [Hahn, Bevra] Univ Calif Los Angeles, Sch Med, Rheumatol, Los Angeles, CA USA; [Hiepe, Falk; Doerner, Thomas] Charite Univ Med Berlin, Rheumatol & Clin Immunol, Berlin, Germany; [Hiepe, Falk; Doerner, Thomas] Free Univ Berlin, Berlin, Germany; [Hiepe, Falk; Doerner, Thomas] Humboldt Univ, Berlin, Germany; [Hiepe, Falk; Doerner, Thomas] Berlin Inst Hlth, Berlin, Germany; [Jacobsen, Soren] Copenhagen Univ Hosp, Copenhagen Lupus & Vasculitis Clin, Dept Rheumatol, Rigshospitalet, Copenhagen, Denmark; [Khanna, Dinesh; McCune, Joseph] Univ Michigan, Div Rheumatol, Ann Arbor, MI 48109 USA; [Lerstrom, Kirsten] Lupus Europe, Romford, Essex, England; [Massarotti, Elena] Brigham & Womens Hosp, Med, 75 Francis St, Boston, MA 02115 USA; [Ruiz-Irastorza, Guillermo] Hosp Univ Cruces, Biocruces Bizkaia Hlth Res Inst, Autoimmune Dis Unit, Baracaldo, Pais Vasco, Spain; [Sanchez-Guerrero, Jorge] Univ Toronto, Mt Sinai Hosp, Med, Univ Hlth Network, Toronto, ON, Canada; [Sanchez-Guerrero, Jorge] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Immunol & Rheumatol, Mexico City, DF, Mexico; [Schneider, Matthias] Heinrich Heine Univ, Fac Med, Policlin & Hiller Res Unit Rheumatol, Dusseldorf, Germany; 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[Assan, Florence; Seror, Raphaele] Univ Paris Sud, Hop Univ Paris Sud, AP HP, INSERM,UMR 1163,UMR 1184, Paris, France; [Chan, Tak Mao] Univ Hong Kong, Dept Med, Pokfulam, Hong Kong, Peoples R China; [Clarke, Ann Elaine] Univ Calgary, Rheumatol, Cumming Sch Med, Calgary, AB, Canada; [Crow, Mary K.] Hosp Special Surg, Mary Kirkland Ctr Lupus Res, 535 E 70th St, New York, NY 10021 USA; [Czirjak, Laszlo; Halda-Kiss, Bernadett; Kumanovics, Gabor] Univ Pecs, Dept Rheumatol & Immunol, Pecs, Hungary; [Doria, Andrea] Univ Padua, Div Rheumatol, Padua, Italy; [Graninger, Winfried B.] Med Univ Graz, Rheumatol & Immunol, Graz, Austria; [Hasni, Sarfaraz] NIAMS, Rheumatol, NIH, Bethesda, MD USA; [Izmirly, Peter M.] NYU, Sch Med, Rheumatol, New York, NY USA; [Jung, Michelle] Univ Calgary, Rheumatol, Calgary, AB, Canada; [Mariette, Xavier] Univ Paris Sud, Hop Univ Paris Sud, AP HP, INSERM UMR, Le Kremlin Bicetre, France; [Padjen, Ivan] Univ Zagreb, Div Clin Immunol & Rheumatol, Sch Med, Zagreb, Croatia; 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J.] Cedars Sinai Med Ctr, Rheumatol, Los Angeles, CA 90048 USA; [Yavuz, Sule] Istanbul Bilim Univ, Rheumatol, Istanbul, Turkey; [Meroni, Pier Luigi] IRCCS Ist Auxol Italiano, Clin Immunol & Rheumatol, Milan, Italy; [Fritzler, Marvin J.] Univ Calgary, Med, Cumming Sch Med, Calgary, AB, Canada; [Naden, Ray] McMaster Univ, Med, Fac Hlth Sci, Hamilton, ON, Canada; [Aringer, Martin] Univ Med Ctr, Rheumatol, Dresden, Germany; [Aringer, Martin] Fac Med Carl Gustav Carus, Dresden, Germanyen_US


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