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dc.contributor.authorKalyoncuoglu, Muhsin
dc.contributor.authorBaskurt, Murat
dc.contributor.authorKaya, Aysem
dc.contributor.authorDogan, Gunes M.
dc.contributor.authorAbaci, Okay
dc.contributor.authorCanbolat, Ismail Polat
dc.contributor.authorKucukoglu, M. Serdar
dc.date.accessioned2020-12-02T18:01:24Z
dc.date.available2020-12-02T18:01:24Z
dc.date.issued2020
dc.identifier.issn2223-4721
dc.identifier.issn2076-0299
dc.identifier.urihttps://doi.org/10.3329/bjms.v19i4.46621
dc.identifier.urihttp://hdl.handle.net/11446/3601
dc.descriptionWOS: 000527244700012en_US
dc.description.abstractObjective: Oxidative stress has been considered to be one of the main causes for the development of pulmonary hypertension (PH) via leading alteration of pulmonary vasomotor tone induced by hypoxia. the aim of this study is to determine the serum paraoxonase-1 enzyme (PON-1) activity, arylesterase activity, the antioxidant-oxidant status in patients with PH and to compare with healthy controls. Material and Methods: Thirty five healthy individuals (mean age 45.7 +/- 5.9 years) as a control group and thirty eight patients (mean age 46.5 +/- 12.6 years) with a diagnosis of PH wereincluded in thestudy. Serum PON-1 and arylesterase activity, the total antioxidative capacity of plasma (TAC) and total oxidantstatus (TOS) were measured by using colorimetric methods. the Oxidative Stress Index (OSI) wascalculated as TOS/ TACX100. Results: Serum PON1 activity is significantly lower in PH patients when compared with healthy controls (p=0.001). the serum arylesterase activity and TAC, TOS and OSI status were similarin bothgroups. There is inverse correlation between serum PON1 activityand NYHA functionalcapacity (r:-0.649 p=0.001). Furthermore, PON1 activity of study patients are similarin the PH subgroups. Serum activity of PON1 wasfoundto bethe only independent parameter for the presence of PH in binary logistic regression analysis (OR 0.984, 95 % CI 0.977-0.992, p=0.001). Eight patients died follow up period (27.6 +/- 14.5 months) and none of theparametersincluding PON1 were associated with mortality. Conclusion: Serum PON1 activity of PH patients is lowerthanhealthypopulation, but does not predictmortality.en_US
dc.language.isoengen_US
dc.publisherIbn Sina Trusten_US
dc.relation.isversionof10.3329/bjms.v19i4.46621en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidative stresen_US
dc.subjectparoxonaseenzymeen_US
dc.subjectpulmonaryhypertensionen_US
dc.subjectarylesteraseen_US
dc.titleParaoxonase-1 Enzyme Activity and Oxidative Status in Pulmonary Hypertension Original Articleen_US
dc.typearticleen_US
dc.relation.journalBangladesh Journal of Medical Scienceen_US
dc.contributor.departmentDBÜen_US
dc.identifier.issue4en_US
dc.identifier.volume19en_US
dc.identifier.startpage652en_US
dc.identifier.endpage658en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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