dc.contributor.author | Oz, Aysegul | |
dc.contributor.author | Server, Sadik | |
dc.contributor.author | Koyuncu Sokmen, Bedriye | |
dc.contributor.author | Namal, Esat | |
dc.contributor.author | Inan, Nagihan | |
dc.contributor.author | Balci, Numan Cem | |
dc.date.accessioned | 2020-12-02T18:01:25Z | |
dc.date.available | 2020-12-02T18:01:25Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1011-7571 | |
dc.identifier.issn | 1423-0151 | |
dc.identifier.uri | https://doi.org/10.1159/000505814 | |
dc.identifier.uri | http://hdl.handle.net/11446/3608 | |
dc.description | WOS: 000567965000004 | en_US |
dc.description | PubMed: 31914438 | en_US |
dc.description.abstract | Objective:This study was aimed at evaluating the intravoxel incoherent motion (IVIM) parameter alterations of liver metastases of colorectal carcinoma (CRC) during antiangiogenic bevacizumab combination therapy.Methods:Twenty-five patients with CRC liver metastases treated with bevacizumab in combination with FOLFOX-or-FOLFIRI protocols were enrolled in the study. MRI was performed using a 1.5-tesla scanner pre-treatment (PT) and at 3, 6, and 9 months of therapy. Routine abdominal MRI sequences and an IVIM-DWI (diffusion-weighted imaging) sequence were obtained. the IVIM-DWI sequence was executed with 16 b-values varying from 0 to 1,400 s/mm(2). the mean values of apparent diffusion coefficient (ADC), true diffusion (D), pseudodiffusion (D*), and perfusion fraction (f) of each metastasis were obtained for all b-values, and the time-related changes were recorded to analyze the chronologic responses to antiangiogenic therapy. the RECIST 1.1 criteria were used for the evaluation of treatment response.Results:The diameters of the metastases diminished significantly at 9 months when compared with PT (p= 0.03). the D (p= 0.10) and ADC (p= 0.21) values of the metastases increased at 9 months of therapy. D* was the highest at 3 months (p =0.24); it decreased at 6 (p =0.97) and 9 months (p =0.87) of therapy. the f value had peaked at 3 months (p =0.51) and started to decrease thereafter. At 6 months, f decreased to the lowest values (p =0.12).Conclusion:IVIM parameters, particularly the perfusion fraction, may quantitatively reflect the response to antiangiogenic treatment. the antiangiogenic response manifests after 3 months of therapy before the RECIST-related response. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Karger | en_US |
dc.identifier.doi | 10.1159/000505814 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Colorectal carcinoma metastasis | en_US |
dc.subject | Bevacizumab | en_US |
dc.subject | Intravoxel incoherent motion | en_US |
dc.subject | Diffusion-weighted MRI | en_US |
dc.title | Intravoxel Incoherent Motion of Colon Cancer Liver Metastases for the Assessment of Response to Antiangiogenic Treatment: Results from a Pilot Study | en_US |
dc.type | article | en_US |
dc.relation.journal | Medical Principles and Practice | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.volume | 29 | en_US |
dc.identifier.startpage | 429 | en_US |
dc.identifier.endpage | 435 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Oz, Aysegul; Server, Sadik; Koyuncu Sokmen, Bedriye; Inan, Nagihan] Istanbul Bilim Univ, Fac Med, Dept Radiol, Buyukdere St 120-1, TR-34394 Istanbul, Turkey; [Namal, Esat] Istanbul Bilim Univ, Fac Med, Dept Med Oncol, Istanbul, Turkey; [Balci, Numan Cem] Cleveland Clin, Dept Radiol, Lerner Sch Med, Abu Dhabi, U Arab Emirates | en_US |