dc.contributor.author | Solmaz, Volkan | |
dc.contributor.author | Kaya, Mahmut | |
dc.contributor.author | Uslu, Fatma Betul | |
dc.contributor.author | Atasoy, Ozum | |
dc.contributor.author | Erbas, Oytun | |
dc.date.accessioned | 2020-12-02T18:01:25Z | |
dc.date.available | 2020-12-02T18:01:25Z | |
dc.identifier.issn | 0894-1939 | |
dc.identifier.issn | 1521-0553 | |
dc.identifier.uri | https://doi.org/10.1080/08941939.2020.1809751 | |
dc.identifier.uri | http://hdl.handle.net/11446/3612 | |
dc.description | WOS: 000562629900001 | en_US |
dc.description | PubMed: 32842806 | en_US |
dc.description.abstract | Aim Our aim was to investigate the possible neuroprotective properties of papaverine in sepsis-induced critical illness neuropathy (SCIN) through the evaluation of various inflammatory biochemical markers, including interleukin 6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha), and oxidative stress biomarkers, such as malondialdehyde (MDA) and lactic acid. Additionally, evaluation of the HMGB1/RAGE interactions in SCIN was another target of this research. Method To create a sepsis model, a procedure involving intraperitoneal injection of feces was performed on 48 rats. the rats were divided into four equal groups: sham operated, controls and those receiving 20 and 40 mg/kg/day papaverine. After five-day treatments, compound muscle action potential (CMAPs) with electroneuromyography (ENMG) was recorded in all rats. Following ENMG evaluations, the plasma levels of sRAGE, HMGB1, TNF-alpha, IL-6, CRP, MDA and lactic acid were measured. Results TNF-alpha, CRP, IL-6, HMGB1, MDA, and lactic acid levels were significantly elevated in the SCIN group, and sRAGE levels were significantly decreased. in recipients of papaverine (20 and 40 mg/kg) treatment, these biochemical findings were improved. Furthermore, electrophysiological findings also showed significant improvement in both 20 and 40 mg/kg papaverine treated groups. Conclusion Papaverine demonstrates neuroprotective effects in a rat model of SCIN. Considering its anti-inflammatory and antioxidant properties, papaverine's neuroprotective effects possibly stem from the suppression of the RAGE-HMGB1 axis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Inc | en_US |
dc.identifier.doi | 10.1080/08941939.2020.1809751 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Critical illness polyneuropathy | en_US |
dc.subject | papaverine | en_US |
dc.subject | CMAP | en_US |
dc.subject | TNF-alpha | en_US |
dc.subject | CRP | en_US |
dc.subject | IL-6 | en_US |
dc.subject | HMGB1 | en_US |
dc.subject | sRAGE | en_US |
dc.subject | MDA | en_US |
dc.subject | and lactic acid | en_US |
dc.title | Papaverine Has Therapeutic Potential for Sepsis-Induced Neuropathy in Rats, Possibly via the Modulation of HMGB1-RAGE Axis and Its Antioxidant Prosperities | en_US |
dc.type | article | en_US |
dc.relation.journal | Journal of Investigative Surgery | en_US |
dc.department | DBÜ | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Solmaz, Volkan] Mem Hizmet Hosp, Dept Neurol, TR-34149 Istanbul, Turkey; [Kaya, Mahmut] Mem Hizmet Hosp, Dept Internal Med, Istanbul, Turkey; [Uslu, Fatma Betul] Batman State Hosp, Dept Anesthesiol, Batman, Turkey; [Atasoy, Ozum] Kartal Dr Lutfi Kirdar Traning & Res Hosp, Radiat Oncol, Istanbul, Turkey; [Erbas, Oytun] Demiroglu Bilim Univ, Dept Physiol, Med Fac, Istanbul, Turkey | en_US |