dc.contributor.author | Arslan, Dilek Betul | |
dc.contributor.author | Gurvit, Hakan | |
dc.contributor.author | Genc, Ozan | |
dc.contributor.author | Kicik, Ani | |
dc.contributor.author | Eryurek, Kardelen | |
dc.contributor.author | Cengiz, Sevim | |
dc.contributor.author | Ozturk-Isik, Esin | |
dc.date.accessioned | 2020-12-02T18:01:27Z | |
dc.date.available | 2020-12-02T18:01:27Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0300-9564 | |
dc.identifier.issn | 1435-1463 | |
dc.identifier.uri | https://doi.org/10.1007/s00702-020-02227-6 | |
dc.identifier.uri | http://hdl.handle.net/11446/3620 | |
dc.description | Yildirim, Zerrin/0000-0002-5128-1784; Eryurek, Kardelen/0000-0003-0482-3963; Gurvit, Hakan/0000-0003-2908-8475; Arslan, Dilek Betul/0000-0002-1124-3695 | en_US |
dc.description | WOS: 000545915200001 | en_US |
dc.description | PubMed: 32632889 | en_US |
dc.description.abstract | Parkinson's disease (PD) with mild cognitive impairment (PD-MCI) is currently diagnosed based on an arbitrarily predefined standard deviation of neuropsychological test scores, and more objective biomarkers for PD-MCI diagnosis are needed. the purpose of this study was to define possible brain perfusion-based biomarkers of not only mild cognitive impairment, but also risky gene carriers in PD using arterial spin labeling magnetic resonance imaging (ASL-MRI). Fifteen healthy controls (HC), 26 cognitively normal PD (PD-CN), and 27 PD-MCI subjects participated in this study. ASL-MRI data were acquired by signal targeting with alternating radio-frequency labeling with Look-Locker sequence at 3 T. Single nucleotide polymorphism genotyping for rs9468 [microtubule-associated protein tau (MAPT) H1/H1 versus H1/H2 haplotype] was performed using a Stratagene Mx3005p real-time polymerase chain-reaction system (Agilent Technologies, USA). There were 15 subjects withMAPTH1/H1 and 11 subjects withMAPTH1/H2 within PD-MCI, and 33 subjects withMAPTH1/H1 and 19 subjects withMAPTH1/H2 within all PD. Voxel-wise differences of cerebral blood flow (CBF) values between HC, PD-CN and PD-MCI were assessed by one-way analysis of variance followed by pairwise post hoc comparisons. Further, the subgroup of PD patients carrying the riskyMAPTH1/H1 haplotype was compared with noncarriers (MAPTH1/H2 haplotype) in terms of CBF by a two-samplettest. A pattern that could be summarized as "posterior hypoperfusion" (PH) differentiated the PD-MCI group from the HC group with an accuracy of 92.6% (sensitivity = 93%, specificity = 93%). Additionally, the PD patients withMAPTH1/H1 haplotype had decreased perfusion than the ones with H1/H2 haplotype at the posterior areas of the visual network (VN), default mode network (DMN), and dorsal attention network (DAN). the PH-type pattern in ASL-MRI could be employed as a biomarker of both current cognitive impairment and future cognitive decline in PD. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1001, 115S219]; Istanbul University Scientific Research Projects Unit Project [1567/42362] | en_US |
dc.description.sponsorship | This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) 1001 Grant #115S219 and Istanbul University Scientific Research Projects Unit Project #1567/42362. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Wien | en_US |
dc.identifier.doi | 10.1007/s00702-020-02227-6 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Arterial spin labeling MRI | en_US |
dc.subject | Cerebral blood flow | en_US |
dc.subject | Parkinson's disease | en_US |
dc.subject | Mild cognitive impairment | en_US |
dc.subject | Microtubule-associated protein tau (MAPT) | en_US |
dc.title | The cerebral blood flow deficits in Parkinson's disease with mild cognitive impairment using arterial spin labeling MRI | en_US |
dc.type | article | en_US |
dc.relation.journal | Journal of Neural Transmission | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.volume | 127 | en_US |
dc.identifier.startpage | 1285 | en_US |
dc.identifier.endpage | 1294 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Arslan, Dilek Betul; Genc, Ozan; Cengiz, Sevim; Ulug, Aziz Mufit; Ozturk-Isik, Esin] Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey; [Gurvit, Hakan; Yildirim, Zerrin; Tufekcioglu, Zeynep; Bilgic, Basar; Hanagasi, Hasmet] Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, Istanbul, Turkey; [Kicik, Ani; Erdogdu, Emel; Demiralp, Tamer] Istanbul Univ, Neuroimaging Unit, Hulusi Behcet Life Sci Res Ctr, Istanbul, Turkey; [Kicik, Ani] Demiroglu Bilim Univ, Fac Med, Dept Physiol, Istanbul, Turkey; [Eryurek, Kardelen; Tuzun, Erdem] Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Neurosci, Istanbul, Turkey; [Erdogdu, Emel] Isik Univ, Fac Arts & Sci, Dept Psychol, Istanbul, Turkey; [Ulug, Aziz Mufit] CorTechs Labs, San Diego, CA USA; [Demiralp, Tamer] Istanbul Univ, Istanbul Fac Med, Dept Physiol, Istanbul, Turkey | en_US |