dc.contributor.author | Ozgur, B. Aydin | |
dc.contributor.author | Coskunpinar, E. | |
dc.contributor.author | Gazioglu, S. Bilgic | |
dc.contributor.author | Yilmaz, A. | |
dc.contributor.author | Oltulu, Y. Musteri | |
dc.contributor.author | Cakmakoglu, B. | |
dc.contributor.author | Yilmaz, M. T. | |
dc.date.accessioned | 2020-12-02T18:01:27Z | |
dc.date.available | 2020-12-02T18:01:27Z | |
dc.identifier.issn | 0882-0139 | |
dc.identifier.issn | 1532-4311 | |
dc.identifier.uri | https://doi.org/10.1080/08820139.2020.1778022 | |
dc.identifier.uri | http://hdl.handle.net/11446/3622 | |
dc.description | Coskunpinar, Ender/0000-0002-1003-5544; Cakmakoglu, Bedia/0000-0001-7960-9131 | en_US |
dc.description | WOS: 000547126500001 | en_US |
dc.description | PubMed: 32611246 | en_US |
dc.description.abstract | CD55 and CD59 are complement regulatory proteins suggested to be related with progression of diabetes and its complications. the stromal cell-derived factor 1 (SDF-1) and C-X-C chemokine receptor type 4 (CXCR-4) are chemokine proteins. We aimed to investigate the relation of CD55 and CD59 expression levels and polymorphisms of SDF-1 and CXCR-4 with type 2 diabetes mellitus (T2DM) and its complications. Seventy-five T2DM patients and 73 controls were enrolled. Expression levels of CD55 and CD59 were measured by FACS Calibur; qRT-PCR was used to determine SDF-1 and CXCR-4 gene polymorphisms. CD55 and CD59 expressions in patients with nephropathy, retinopathy and cardiovascular disease were significantly lower than controls. Frequency of CXCR-4 T allele carrying was high in patients and created 1.6 fold risk for the disease (p= .07). CXCR-4 a allele carriers had decreased nephropathy; although there was no statistical significance in carrying CXCR-4 T allele, presence of nephropathy was approximately 2 times higher (p= .254). the nephropathy risk increased 10-fold in CXCR-4 TT genotype carriers (p= .02). All SDF-1 CC genotype carriers had retinopathy, so, it was considered that the CC genotype was effective in retinopathy development (p= .031). For the presence of cardiovascular disease, significant difference was observed for SDF-1 genotypes. Increased cardiovascular risk of 5- and 1.9-fold in SDF-1 T (p= .007) and CXCR-4 T (p= .216) allele carriers, respectively, was observed. We suggest that CD55 and CD59 protein levels and SDF-1 and CXCR-4 have predictive importance in process, complications and tendency of T2DM. | en_US |
dc.description.sponsorship | Istanbul University Scientific Projects Coordination UnitIstanbul University [11630] | en_US |
dc.description.sponsorship | Istanbul University Scientific Projects Coordination Unit - 11630 | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Inc | en_US |
dc.identifier.doi | 10.1080/08820139.2020.1778022 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Type 2 diabetes | en_US |
dc.subject | CD55 | en_US |
dc.subject | CD59 | en_US |
dc.subject | SDF-1 | en_US |
dc.subject | CXCR-4 | en_US |
dc.title | Effects of Complement Regulators and Chemokine Receptors in Type 2 Diabetes | en_US |
dc.type | article | en_US |
dc.relation.journal | Immunological Investigations | en_US |
dc.department | DBÜ | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Ozgur, B. Aydin; Gazioglu, S. Bilgic; Yilmaz, A.; Deniz, G.; Gurol, A. O.] Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Immunol, Istanbul, Turkey; [Ozgur, B. Aydin] Demiroglu Bilim Univ, Fac Med, Dept Med Biol & Genet, Istanbul, Turkey; [Coskunpinar, E.] Hlth Sci Univ, Fac Med, Dept Med Biol, Istanbul, Turkey; [Oltulu, Y. Musteri] Biruni Univ, Fac Med, Dept Med Biol, Istanbul, Turkey; [Cakmakoglu, B.] Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Mol Med, Istanbul, Turkey; [Yilmaz, M. T.] Istanbul Univ, Dept Endocrinol & Metab, Internal Med, Fac Istanbul Med, Istanbul, Turkey; [Yilmaz, M. T.] Demiroglu Bilim Univ, Fac Med, Dept Endocrinol & Metab, Internal Med, Istanbul, Turkey | en_US |