dc.contributor.author | Gozubatik Celik, R. Gokcen | |
dc.contributor.author | Koksal, Ayhan | |
dc.contributor.author | Sahin, Buket | |
dc.contributor.author | Sen, Aysu | |
dc.contributor.author | Karagoz Sakalli, Nazan | |
dc.contributor.author | Nalbantoglu, Mecbure | |
dc.date.accessioned | 2020-12-02T18:01:34Z | |
dc.date.available | 2020-12-02T18:01:34Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1300-0667 | |
dc.identifier.issn | 1309-4866 | |
dc.identifier.uri | https://doi.org/10.29399/npa.24761 | |
dc.identifier.uri | http://hdl.handle.net/11446/3657 | |
dc.description | WOS: 000531813000008 | en_US |
dc.description | PubMed: 32110148 | en_US |
dc.description.abstract | Introduction: in this study, we aimed to investigate the effect of uric acid on the disease, its severity and progression in ET patients with partially co-clinical features with Parkinson's disease (PD). Methods: Serum UA levels of 87 consecutive ET patients were measured and were matched according to age and sex with 87 healthy controls. Fahn-Tolosa-Marin scale was used for the severity of tremor. Sociodemographic characteristics, type of ET, duration of disease, and treatment modalities were evaluated. Results: the mean uric acid level was calculated as 4.986 +/- 2.1458 mg/c11.. and 6.004 +/- 1.523 mg/dL in the patient and control groups, respectively (p <= 0.005). the blood UA level of patients with sporadic (n: 61) ET was found to be lower than the familial ET (n: 26) (p <= 0.005). the tremor severity of the family ET patients was lower than the sporadic ET (n: 61) (p <= 0.005). the mean blood UA level (4.429 +/- 1.216 mg/dL) in the patients with high total tremor severity scores (n: 48) was found lower than in the patients with low total tremor severity scores (n: 39) (5.673 +/- 2.106 mg/dL) (P=0.000). the serum UA level was significantly lower in the patients whose disease duration longer than 5 years than in patients whose duration of the disease was shorter than 5 years. 5.732 +/- 1.240 for >= 5 years; 6.438 +/- 0.286 <= 5 years) (P=0.001). Conclusion: We hypothesize that as a result of high antioxidant properties of high serum uric acid levels, it is a biomarker that can show disease risk and progression in patients with ET as well as PD. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi | en_US |
dc.identifier.doi | 10.29399/npa.24761 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Essential tremor | en_US |
dc.subject | uric acid | en_US |
dc.subject | Fahn-Tolosa-Marin tremor scale | en_US |
dc.subject | familial essential tremor | en_US |
dc.subject | sporadic essential tremor | en_US |
dc.subject | antioxidant effect | en_US |
dc.title | The Relationship Between Serum Uric Acid Levels and Clinical Features in Essential Tremor | en_US |
dc.type | article | en_US |
dc.relation.journal | Noropsikiyatri Arsivi-Archives of Neuropsychiatry | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.volume | 57 | en_US |
dc.identifier.startpage | 33 | en_US |
dc.identifier.endpage | 36 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Gozubatik Celik, R. Gokcen; Koksal, Ayhan; Sahin, Buket; Sen, Aysu; Karagoz Sakalli, Nazan] Bakirkoy Res & Training Hosp Neurol & Psychiat Di, Dept Neurol, Istanbul, Turkey; [Nalbantoglu, Mecbure] Bilim Univ, Dept Neurol, Sch Med, Istanbul, Turkey | en_US |