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dc.contributor.authorKaya, Huseyin
dc.contributor.authorSabah, Dundar
dc.contributor.authorKececi, Burcin
dc.contributor.authorKucuk, Levent
dc.contributor.authorErbas, Oytun
dc.contributor.authorOltulu, Fatih
dc.contributor.authorTaskiran, Dilek
dc.date.accessioned2020-12-02T18:01:36Z
dc.date.available2020-12-02T18:01:36Z
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.urihttps://doi.org/10.1080/08941939.2019.1691686
dc.identifier.urihttp://hdl.handle.net/11446/3669
dc.descriptionWOS: 000512563000001en_US
dc.descriptionPubMed: 32013622en_US
dc.description.abstractAim of the study: Biologic reconstruction using tumor-bearing bone autografts devitalized by liquid nitrogen or extracorporeal irradiation (oncological sterilization) is a safe and effective method in musculoskeletal surgery. the purpose of this study was to examine the effects of these two oncological sterilization methods on nerve recovery. Methods: A total of 48 rats were randomly divided into 3 groups as autograft, irradiation and liquid nitrogen groups. A nerve defect created in the right sciatic nerve was reconstructed with an autograft obtained from the nerve itself. Group I underwent reconstruction with standard nerve autograft. Group II and Group III underwent reconstruction with devitalized nerve autograft treated through extracorporeal irradiation and liquid nitrogen, respectively. the left sciatic nerves of the rats served as control. Electromyography, motor function test and histomorphological analysis were performed to assess the nerve recovery on the 3rd (early stage) and 4th months (late stage). Results: Electrophysiological assessment revealed better results in irradiation group compared with liquid nitrogen group in terms of myelinization and axonal regeneration. Motor performance of the autograft group was slightly better than the other groups. Histologically, autograft group demonstrated better results compared with other groups. Late-stage assessments revealed high rates of myelinization in the graft segment in liquid nitrogen group and in the segment distal to the graft in irradiation group. Conclusions: This study has demonstrated that nerve autografts treated by oncological sterilization methods may be used for nerve reconstruction in limb salvage surgery. However, further studies are needed to clarify the applicability of these methods.en_US
dc.description.sponsorshipEge University Scientific Research FoundationEge University [15-TIP-013]en_US
dc.description.sponsorshipThis work was supported by Ege University Scientific Research Foundation (15-TIP-013).en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Incen_US
dc.identifier.doi10.1080/08941939.2019.1691686en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNerve recoveryen_US
dc.subjectlimb salvageen_US
dc.subjectextracorporeal irradiationen_US
dc.subjectliquid nitrogenen_US
dc.subjectnerve autograften_US
dc.subjectbone tumoren_US
dc.titleComparison of the Effects of Extracorporeal Irradiation and Liquid Nitrogen on Nerve Recovery in a Rat Modelen_US
dc.typearticleen_US
dc.relation.journalJournal of Investigative Surgeryen_US
dc.departmentDBÜen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Kaya, Huseyin; Sabah, Dundar; Kececi, Burcin; Kucuk, Levent] Ege Univ, Fac Med, Dept Orthoped & Traumatol, Izmir, Turkey; [Erbas, Oytun] Istanbul Bilim Univ, Fac Med, Dept Physiol, Istanbul, Turkey; [Oltulu, Fatih] Ege Univ, Fac Med, Dept Histol & Embryol, Izmir, Turkey; [Yigitturk, Gurkan] Mugla Sitki Kocman Univ, Fac Med, Dept Histol & Embryol, Mugla, Turkey; [Taskiran, Dilek] Ege Univ, Fac Med, Dept Physiol, Izmir, Turkeyen_US


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