dc.contributor.author | Bademci, Refik | |
dc.contributor.author | Erdogan, Mumin Alper | |
dc.contributor.author | Kara, Ali Yucel | |
dc.contributor.author | Yigitturk, Gurkan | |
dc.contributor.author | Erbas, Oytun | |
dc.date.accessioned | 2020-12-02T18:01:38Z | |
dc.date.available | 2020-12-02T18:01:38Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0102-8650 | |
dc.identifier.issn | 1678-2674 | |
dc.identifier.uri | https://doi.org/10.1590/s0102-865020200040000004 | |
dc.identifier.uri | http://hdl.handle.net/11446/3680 | |
dc.description | Erdogan, Mumin/0000-0003-0048-444X | en_US |
dc.description | WOS: 000540300900001 | en_US |
dc.description | PubMed: 32555936 | en_US |
dc.description.abstract | Purpose: To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. Methods: A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 mu g/kg for 5 days. Results: Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p<0.01). in the Calcitriol group, there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group (p<0.000). Conclusion: the findings suggest that calcitriol may be an agent that could be used in acute colitis treatment. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Acta Cirurgica Brasileira | en_US |
dc.identifier.doi | 10.1590/s0102-865020200040000004 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Calcitriol | en_US |
dc.subject | Colitis | en_US |
dc.subject | Tumor Necrosis Factor-alpha | en_US |
dc.subject | Malondialdehyde | en_US |
dc.subject | Rats | en_US |
dc.title | Therapeutic effects of vitamin D on acetic acid-induced colitis in rats | en_US |
dc.type | article | en_US |
dc.relation.journal | Acta Cirurgica Brasileira | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.volume | 35 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Bademci, Refik] Istanbul Medipol Univ, Dept Gen Surg, Istanbul, Turkey; [Erdogan, Mumin Alper; Kara, Ali Yucel; Yigitturk, Gurkan] Izmir Katip Celebi Univ, Fac Med, Dept Physiol, Izmir, Turkey; [Erbas, Oytun] Ege Univ, Fac Med, Dept Histol & Embryol, Izmir, Turkey; Istanbul Bilim Univ, Dept Physiol, Istanbul, Turkey | en_US |