dc.contributor.author | Akarsu, Emel Oguz | |
dc.contributor.author | Sirin, Nermin Gorkem | |
dc.contributor.author | Orhan, Elif Kocasoy | |
dc.contributor.author | Erbas, Bahar | |
dc.contributor.author | Dede, Hava Ozlem | |
dc.contributor.author | Baslo, Mehmet Baris | |
dc.contributor.author | Oge, Ali Emre | |
dc.date.accessioned | 2020-12-02T18:01:39Z | |
dc.date.available | 2020-12-02T18:01:39Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1388-2457 | |
dc.identifier.issn | 1872-8952 | |
dc.identifier.uri | https://doi.org/10.1016/j.clinph.2019.09.030 | |
dc.identifier.uri | http://hdl.handle.net/11446/3686 | |
dc.description | sirin, Nermin Gorkem/0000-0001-8792-2929; | en_US |
dc.description | WOS: 000502603500012 | en_US |
dc.description | PubMed: 31760213 | en_US |
dc.description.abstract | Objective: To extract insight about the mechanism of repeater F-waves (Frep) by exploring their correlation with electrophysiologic markers of upper and lower motor neuron dysfunction in amyotrophic lateral sclerosis (ALS). Methods: the correlations of Frep parameters with clinical scores and the results of neurophysiological index (NI), MScanfit MUNE, F/M amplitude ratio (F/M%), single and paired-pulse transcranial magnetic stimulation (TMS), and triple stimulation technique (TST) studies, recorded from abductor digiti minimi (ADM) and abductor pollicis brevis (APB) muscles of 35 patients with ALS were investigated. Results: Frep parameters were correlated with NI and MScanfit MUNE in ADM muscle and F/M% in both muscles. None of the Frep parameters were correlated with clinical scores or TST and TMS measures. While the CMAP amplitudes were similar in the two recording muscles, there was a more pronounced decrease of F-wave persistence in APB, probably heralding the subsequent split hand phenomenon. Conclusion: Our findings suggest that the presence and density of Freps are primarily related to the degree of lower motor neuron loss and show no correlation with any of the relatively extensive set of parameters for upper motor neuron dysfunction. Significance: Freps are primarily related to lower motor neuron loss in ALS. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Ireland Ltd | en_US |
dc.identifier.doi | 10.1016/j.clinph.2019.09.030 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Repeater F-wave | en_US |
dc.subject | Amyotrophic lateral sclerosis | en_US |
dc.subject | Triple stimulation technique | en_US |
dc.subject | MScanFit MUNE | en_US |
dc.subject | Transcranial magnetic stimulation | en_US |
dc.subject | Split hand | en_US |
dc.title | Repeater F-waves in amyotrophic lateral sclerosis: Electrophysiologic indicators of upper or lower motor neuron involvement? | en_US |
dc.type | article | en_US |
dc.relation.journal | Clinical Neurophysiology | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.volume | 131 | en_US |
dc.identifier.startpage | 96 | en_US |
dc.identifier.endpage | 105 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Akarsu, Emel Oguz; Sirin, Nermin Gorkem; Orhan, Elif Kocasoy; Erbas, Bahar; Dede, Hava Ozlem; Baslo, Mehmet Baris; Idrisoglu, Halil Atilla; Oge, Ali Emre] Istanbul Univ, Istanbul Fac Med, Dept Neurol, TR-34390 Istanbul, Turkey; [Erbas, Bahar] Demiroglu Bilim Univ, Fac Med, Dept Pharmacol, Istanbul, Turkey | en_US |