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dc.contributor.authorAtik, Tugba Kula
dc.contributor.authorOzyurt, Mustafa
dc.contributor.authorAtik, Bulent
dc.contributor.authorBektore, Bayhan
dc.contributor.authorSelek, Burak M.
dc.contributor.authorCetinkaya, Riza Aytac
dc.contributor.authorBaylan, Orhan
dc.date.accessioned2020-12-02T18:01:46Z
dc.date.available2020-12-02T18:01:46Z
dc.date.issued2019
dc.identifier.issn1305-2381
dc.identifier.urihttp://hdl.handle.net/11446/3719
dc.descriptionAtik, Bulent/0000-0002-6876-2963; Baylan, Orhan/0000-0002-6529-7824en_US
dc.descriptionWOS: 000508954100007en_US
dc.description.abstractObjective: Our study aimed to reveal the OXA-like carbapenernase genes and molecular epidemiological relationship in A. baumannii isolates and compare antibiotic susceptibility status-resistance genes-Pulsed Field Gel Electrophoresis (PFGE) patterns. Material and Method: A total of 100 A. baumannii isolates obtained from several clinical specimens were examined by VITEK2 automated identification system (Biomerieux, France) for the antibiotic susceptibility profile, by multiplex polymerase chain reaction (PCR) method for OXA-type beta-lactamuses and by PFGE method for the clonal relationship. Results: 57% of the isolates were obtained from respiratory system specimens. Among all the antibiotics, colistin was the most effective agent with 100% sensitivity, followed by tigecycline with 93%. All of the isolates were resistant to piperacillin, piperacillinitazobaaam and ciprofloxacin. Resistance against both imipenem and meropenem were detected as 95%. OXA-51 gene was found in all and oxil-23 gene was found in 92 (92%) of the isolates. None of the isolates had OXA-24 or OXA-58 genes. We identified 19 different clonal clusters among 100 isolates by PFGE method. We revealed that some of the clones were clustered in a certain period of time, and this was supported by the antibiogram results and OXA gene profiling. Conclusion: Our study identified high rates OXA-23 gene locus positivity, presented the current clonal similarity and time relationship among the clonal clusters. These results emphasize the importance of molecular epidemiological methods as well as standard infection control programs to prevent spreading of A. baumannii.en_US
dc.language.isoengen_US
dc.publisherNobel Ilacen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcinetobacter baurnunniien_US
dc.subjectantibiotic resistanceen_US
dc.subjectoxa-type carbapenemasesen_US
dc.subjectpolymerase chain reaction (PCR)en_US
dc.subjectpulsed field gel electrophoresis (PFGE)en_US
dc.titleIDENTIFICATION OF OXA-GENE IN ACINETOBACTER BAUMANNII ISOLATES OBTAINED FROM CLINICAL SPECIMENS AND THE CLONALITY BETWEEN THESE ISOLATESen_US
dc.typearticleen_US
dc.relation.journalNobel Medicusen_US
dc.departmentDBÜen_US
dc.identifier.issue3en_US
dc.identifier.volume15en_US
dc.identifier.startpage44en_US
dc.identifier.endpage51en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Atik, Tugba Kula] Balikesir Ataturk City Hosp, Dept Microbiol, Balikesir, Turkey; [Ozyurt, Mustafa] Istanbul Bilim Univ, Dept Microbiol, Istanbul, Turkey; [Atik, Bulent] Balikesir Ataturk City Hosp, Dept Anesthesiol & Reanimat, Balikesir, Turkey; [Bektore, Bayhan] Kars Harakani Publ Hosp, Dept Microbiol, Kars, Turkey; [Selek, Burak M.; Baylan, Orhan] Hlth Sci Univ, Dept Microbiol, Sultan Abdulhamid Han Training & Res Hosp, Istanbul, Turkey; [Cetinkaya, Riza Aytac; Yenilmez, Ercan] Hlth Sci Univ, Dept Infect Dis, Sultan Abdulhamid Han Training & Res Hosp, Istanbul, Turkeyen_US


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