Catheter-Related Bloodstream Infections: A Multicentric Five-Year Analysis

Abstract

Objective: the aim of this study was to evaluate the catheter-related bloodstream infections (CR-BSI) devoloping in hematology and oncology departments, and intensive care units of three different hospitals from a clinical and microbiological point of view. Methods: We retrospectively evaluated the CR-BSI in hematology and oncology departments and intensive care units, and by using laboratory- and clinic-based active surveillance systems between January 2013 and December 2017 based on the definition criteria for US Centers for Disease Control and Prevention. the demographic characteristics of the patients, clinical information, catheter-related information such as the unit which the catheter was inserted, erythema in the catheter insertion site, and results of blood cultures were recorded. Isolated agents were identified by MicroScan autoSCAN-4 (Beckman Coulter, Brea, CA, USA) automatized system in addition to conventional methods. Statistical analyses were performed using MedCalc Statistical Software Version 12.7.7 (MedCalc Software bvba, Ostend, Belgium). Results: CR-BSI was detected in 46 (45% female) patients. the mean age was 61 +/- 19. 24 (52.2%) patients had permanent catheterization (port) and 22 (47.8%) had central venous catheter. Blood culture was obtained in 40 (87%) patients and there was >2 hours of interval in 24 patients. 9 (20%) had erythema at the catheter insertion site. 3 (6.5%) patients died of the infection. Duration of the treatment was 13 +/- 4 days. Gram-negatives, Gram-positives, and fungi were detected in 50%, 25.4% and 23.9% of isolates, respectively. Within 10 days after catheter and port implantation, Gram-negatives and fungi were grown, and it was statistically significant that there was no Gram-positive growth during this period. Conclusions: Analysis of surveillance data, distribution of isolated microorganisms, knowledge of antibiotic sensitivities and prediction of risk factors are important for prevention and rapid and successful treatment of CR-BSI.