Effects of montelukast on the healing of ischemic colon anastomoses
Çelik, Aysun Şimşek
Uzun, Mehmet Ali
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Celik A, Ergun E, Koksal N, Celik AS, Altinli E, Uzun MA, Eroglu E, Kemik A. Effects of montelukast on the healing of ischemic colon anastomoses. American Journal of Surgery. 2013; 206(4): 502-8. doi: 10.1016/j.amjsurg.2013.03.003.
BACKGROUND: The aim of this study was to examine whether treatment with montelukast, a selective leukotriene antagonist, would affect anastomotic healing in a reperfused colon rat model with remote ischemia/reperfusion injury. METHODS: Rats (n 5 12 per group) were intraperitoneally administered normal saline or 10 mg/kg montelukast sodium 60 minutes before and for 5 days after surgery. Ischemia was induced for 45 minutes through superior mesenteric artery occlusion. A left colon anastomosis was made. Blood and perianastomotic tissue samples were obtained on postoperative day 5. RESULTS: Mean anastomotic bursting pressures of the control and montelukast groups were 159.17 6 29.99 and 216.67 6 26.40, respectively (P , .001). Compared with saline, montelukast treatment increased the mean tissue hydroxyproline level (2.46 6 .30 vs 3.61 6 .33 mmol/L) and decreased tissue caspase-3 activity (36.06 6 5.72 vs 21.78 6 3.87) and malondialdehyde levels (3.43 6 .34 vs 2.29 6 .34 nmol/g) (P , .001 for all). Other plasma markers of injury also showed differences. CONCLUSIONS: Montelukast prevented ischemia/reperfusion-induced damage in a rat model of colonic anastomotic wound healing.
SourceAmerican Journal of Surgery