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dc.contributor.authorÇelik, Atilla
dc.contributor.authorErgun, Ersin
dc.contributor.authorKöksal, Neşet
dc.contributor.authorÇelik, Aysun Şimşek
dc.contributor.authorAltınlı, Ediz
dc.contributor.authorUzun, Mehmet Ali
dc.contributor.authorKemik, Ahu
dc.date.accessioned2014-08-04T11:42:32Z
dc.date.available2014-08-04T11:42:32Z
dc.date.issued2013
dc.identifier.citationhttps://www.clinicalkey.com/#!/ContentPlayerCtrl/doPlayContent/1-s2.0-S0002961013003048en_US
dc.identifier.citationCelik A, Ergun E, Koksal N, Celik AS, Altinli E, Uzun MA, Eroglu E, Kemik A. Effects of montelukast on the healing of ischemic colon anastomoses. American Journal of Surgery. 2013; 206(4): 502-8. doi: 10.1016/j.amjsurg.2013.03.003.en_US
dc.identifier.issn0002-9610
dc.identifier.urihttps://www.clinicalkey.com/#!/ContentPlayerCtrl/doPlayContent/1-s2.0-S0002961013003048en_US
dc.identifier.urihttps://hdl.handle.net/11446/392en_US
dc.descriptionİstanbul Bilim Üniversitesi, Tıp Fakültesi.en_US
dc.description.abstractBACKGROUND: The aim of this study was to examine whether treatment with montelukast, a selective leukotriene antagonist, would affect anastomotic healing in a reperfused colon rat model with remote ischemia/reperfusion injury. METHODS: Rats (n 5 12 per group) were intraperitoneally administered normal saline or 10 mg/kg montelukast sodium 60 minutes before and for 5 days after surgery. Ischemia was induced for 45 minutes through superior mesenteric artery occlusion. A left colon anastomosis was made. Blood and perianastomotic tissue samples were obtained on postoperative day 5. RESULTS: Mean anastomotic bursting pressures of the control and montelukast groups were 159.17 6 29.99 and 216.67 6 26.40, respectively (P , .001). Compared with saline, montelukast treatment increased the mean tissue hydroxyproline level (2.46 6 .30 vs 3.61 6 .33 mmol/L) and decreased tissue caspase-3 activity (36.06 6 5.72 vs 21.78 6 3.87) and malondialdehyde levels (3.43 6 .34 vs 2.29 6 .34 nmol/g) (P , .001 for all). Other plasma markers of injury also showed differences. CONCLUSIONS: Montelukast prevented ischemia/reperfusion-induced damage in a rat model of colonic anastomotic wound healing.en_US
dc.language.isoengen_US
dc.publisherElsevier Incen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectischemia/reperfusionen_US
dc.subjectcolon anastomosesen_US
dc.subjectmontelukasten_US
dc.titleEffects of montelukast on the healing of ischemic colon anastomosesen_US
dc.typearticleen_US
dc.relation.journalAmerican Journal of Surgeryen_US
dc.contributor.departmentDBÜ, Tıp Fakültesien_US
dc.identifier.issue4
dc.identifier.volume206
dc.identifier.startpage502
dc.identifier.endpage508
dc.contributor.authorIDTR115045en_US
dc.contributor.authorIDTR120637en_US
dc.contributor.authorIDTR47711en_US
dc.relation.publicationcategoryBelirsizen_US


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