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dc.contributor.authorAkman, Özlem
dc.contributor.authorDemiralp, Tamer
dc.contributor.authorAtes, Nurbay
dc.contributor.authorOnat, Filiz Yilmaz
dc.date.accessioned2014-08-06T12:50:32Z
dc.date.available2014-08-06T12:50:32Z
dc.date.issued2010
dc.identifier.citationAkman O, Demiralp T, Ates N, Onat FY. Electroencephalographic differences between WAG/Rij and GAERS rat models of absence epilepsy. Epilepsy Research. 2010; 89(2-3): 185-193. doi: 10.1016/j.eplepsyres.2009.12.005.en_US
dc.identifier.issn1872-6844
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0920121109003817en_US
dc.identifier.urihttps://hdl.handle.net/11446/406en_US
dc.descriptionİstanbul Bilim Üniversitesi, Tıp Fakültesi.en_US
dc.description.abstractThe inbred Wistar Albino Glaxo Rats from Rijswijk (WAG/Rij) and the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are well-validated genetic models of absence epilepsy. Although they share similar characteristics including the spike-and-wave discharges (SWDs) in the EEG, some differences have been reported between both strains. This study aimed a systematic and detailed comparison of the SWD patterns of both strains in terms of the intensity, frequency and waveform morphology of the discharges by using exactly the same measurement and analysis techniques. The number, cumulative total duration and mean duration of SWDs were significantly higher in GAERS compared to WAG/Rij, while the discharge frequency was higher in the WAG/Rij. Furthermore, SWDs spectra and average SWD waveforms indicated that a single cycle of the SWD contains more energy in faster components such as spike and late positive transient in the GAERS. Additionally, WAG/Rij exhibited a significantly higher power between 8 and 14 Hz during the pre-SWD period. These clear phenomenological differences in the EEGs of both animal models suggest that these variables may represent basic phenotypic features of SWDs that should be sought after in the future studies that explore the genetic and molecular basis of absence epilepsy.en_US
dc.language.isoengen_US
dc.publisherElsevier Incen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectWAG/Rijen_US
dc.subjectGAERSen_US
dc.subjectspike-and-wave dischargesen_US
dc.subjectpower spectrumen_US
dc.subjectfrequency domainen_US
dc.subjectwaveform morphologyen_US
dc.titleElectroencephalographic differences between WAG/Rij and GAERS rat models of absence epilepsyen_US
dc.typearticleen_US
dc.relation.journalEpilepsy Researchen_US
dc.contributor.departmentDBÜ, Tıp Fakültesien_US
dc.identifier.issue2-3
dc.identifier.volume89
dc.identifier.startpage185
dc.identifier.endpage193
dc.contributor.authorIDTR45271en_US
dc.contributor.authorIDTR6916en_US
dc.contributor.authorIDTR25866en_US
dc.contributor.authorIDTR122028en_US
dc.relation.publicationcategoryBelirsizen_US


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