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dc.contributor.authorİşeri, Pervin K.
dc.contributor.authorKarson, Ayşe
dc.contributor.authorGüllü, Kemal M.
dc.contributor.authorAkman, Özlem
dc.contributor.authorKöktürk, Sibel
dc.contributor.authorYardımoğlu, Melda
dc.contributor.authorAteş, Nurbay
dc.date.accessioned2014-08-06T13:56:34Z
dc.date.available2014-08-06T13:56:34Z
dc.date.issued2011
dc.identifier.citationIseri PK, Karson A, Gullu KM, Akman O, Kokturk S, Yardimoglu M, Erturk S, Ates N. The effect of memantine in harmaline-induced tremor and neurodegeneration. Neuropharmacology. 2011; 61(4): 715-723. doi: 10.1016/j.neuropharm.2011.05.015.en_US
dc.identifier.issn1873-7064
dc.identifier.urihttp://www.sciencedirect.com/en_US
dc.identifier.urihttps://hdl.handle.net/11446/409en_US
dc.descriptionİstanbul Bilim Üniversitesi, Tıp Fakültesi.en_US
dc.description.abstractEssential tremor (ET) is one of the most common and most disabling movement disorders among adults. The drug treatment of ET remains unsatisfactory. Additional therapies are required for patients with inadequate response or intolerable side effects. The current study aims to investigate the anti-tremogenic and neuroprotective effects of memantine (NMDA receptor antagonist) on the harmaline model of transient action tremor. The effects of memantine were further compared with ethanol. Three separate groups of male Wistar rats were injected either with saline, ethanol (1.5 gr/kg), or memantine (5 mg/kg) 15 min prior to a single intraperitoneal injection of harmaline (20 mg/kg). Tremor and locomotion were evaluated by a custom-built tremor and locomotion analysis system. After 24 h of harmaline injection, cellular viability, and apoptosis were assessed using crystal violet staining, and caspase-3 immunostaining, respectively. Harmaline caused neuronal cell loss and caspase-3 mediated apoptosis in cerebellar granular and purkinje cells as well as the inferior olivary neurons. Despite a reduction in tremor intensity and duration with ethanol, this compound resulted in cell loss in cerebellum and olivary nucleus. Memantine exhibited neuroprotective efficacy on cerebellar and inferior olivary neurons albeit weaker anti-tremor effect compared to ethanol. In conclusion, anti-tremogenic and neuroprotective effects do not necessarily overlap. Memantine is a potential treatment for ET particularly given its neuroprotective efficacy.en_US
dc.language.isoengen_US
dc.publisherElsevier Incen_US
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S002839081100205Xen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectmemantineen_US
dc.subjectharmaline-induced tremoren_US
dc.subjectN-neuroprotectionen_US
dc.subjecttremor and locomotion analysis systemen_US
dc.titleThe effect of memantine in harmaline-induced tremor and neurodegenerationen_US
dc.typearticleen_US
dc.relation.journalNeuropharmacologyen_US
dc.contributor.departmentDBÜ, Tıp Fakültesien_US
dc.identifier.issue4
dc.identifier.volume61
dc.identifier.startpage715
dc.identifier.endpage723
dc.contributor.authorIDTR12590en_US
dc.contributor.authorIDTR155950en_US
dc.contributor.authorIDTR154066en_US
dc.contributor.authorIDTR45271en_US
dc.contributor.authorIDTR112473en_US
dc.contributor.authorIDTR10337en_US
dc.contributor.authorIDTR154063en_US
dc.contributor.authorIDTR25866en_US
dc.relation.publicationcategoryBelirsizen_US


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